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Human Leukocyte Antigen Alleles (Hla-A, Hla-B, and Hladrb1) Are Associated With Acute Lymphoblastic Leukemia (All): A Case-Control Study in a Sample of Iranian Population Publisher Pubmed



Mk Vajari Mahdi KOHANSAL ; M Ehsan MOHSEN ; S Ghiasi SAEEDEH ; S Fooladi SABA ; N Karami NAJIBE ; Gs Hassanshahi Dr Gholamhossein SEIN ; A Fatemi AHMAD
Authors

Source: Asian Pacific Journal of Cancer Prevention Published:2024


Abstract

Objective: This study seeks to elucidate the association between HLA-A, HLA-B, and HLA-DRB1 alleles and their relative risk contributions to ALL within an Iranian cohort. Methods: Utilizing a robust case-control design, this research involved 71 ALL patients and 71 age and sex-matched healthy individuals. Genotyping of specified HLA alleles was performed using the advanced PCR-SSP technique. Results: Our findings reveal a marked increase in the prevalence of the HLA-DRB1*04 allele among patients diagnosed with ALL compared to the control group (P<0.027). Conversely, the alleles HLA-A*26 (P=0.025), HLA-A*33 (P=0.020), and HLA-DRB1*03 (P=0.035) were observed at significantly reduced frequencies within the patient population. Conclusion: Our findings highlight HLA-DRB1*04 as a potential genetic marker for increased susceptibility to ALL, while HLA-A*26, HLA-A*33, and HLA-DRB1*03 emerge as protective factors. © 2024 Elsevier B.V., All rights reserved.
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