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Electrospun Gold Nanorods/Graphene Oxide Loaded-Core-Shell Nanofibers for Local Delivery of Paclitaxel Against Lung Cancer During Photo-Chemotherapy Method Publisher Pubmed



Azerbaijan MH1 ; Bahmani E2 ; Jouybari MH3 ; Hassaniazardaryani A4 ; Goleij P5 ; Akrami M6 ; Irani M7
Authors
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Authors Affiliations
  1. 1. Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus via Mersin 10, Turkey
  2. 2. Department of Chemical Engineering, Payame Noor University, Tehran, Iran
  3. 3. Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Mechanical Engineering, Khaje Nasir University of Technology, Tehran, Iran
  5. 5. Department of Genetics, Faculty of Biology, Sana Institute of Higher Education, Sari, Iran
  6. 6. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran

Source: European Journal of Pharmaceutical Sciences Published:2021


Abstract

The combinations of photothermal therapy (PTT) and chemotherapy (CHT) have attracted increasing attention for cancer therapy. In the present study, paclitaxel as an anticancer drug and graphene oxide/gold nanorods (GO/Au NRs) were simultaneously loaded into the poly (tetramethylene ether) glycol based-polyurethane (PTMG-PU) (core)/chitosan (shell) nanofibers prepared by the coaxial electrospinning method. The potential of the synthesized nanofiber as a pH/temperature dual responsive carrier was investigated for the controlled release of paclitaxel against A549 lung cancer during PTT/CHT combined method. The synthesized core-shell nanofibers were characterized using SEM, TEM and XRD analysis. The drug encapsulation efficiency, drug release and kinetic studies were carried out. The compatibility of the synthesized core-shell nanofibers was also investigated. The cell viability of the synthesized nanofibers treated with A549 lung cancer cells was investigated under alone CHT, alone PTT and PTT/CHT method. The in vivo studies indicated that the PTT/CHT method demonstrated an optimal therapeutic effect on tumor inhibition without change in body weight. The obtained results demonstrated that the synthesized core-shell nanofibers would be used for lung cancer treatment under NIR irradiation in the future. © 2021
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