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Lanthanum-Based Metal Organic Framework (La-Mof) Use of 3,4-Dihydroxycinnamic Acid As Drug Delivery System Linkers in Human Breast Cancer Therapy Publisher



Safinejad M1 ; Rigi A2 ; Zeraati M3 ; Heidary Z4 ; Jahani S5 ; Chauhan NPS6 ; Sargazi G5
Authors
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Authors Affiliations
  1. 1. RF MEMS & Micro Bio-Nano Electronics (MBNE) Lab, Department of Electrical Engineering, Shahid Bahonar University of Kerman, Kerman, Iran
  2. 2. Department of Nursing, Young Researchers and Elite Club, Zahedan Branch, Islamic Azad University, Zahedan, Iran
  3. 3. Department of Materials Engineering, Shahid Bahonar University of Kerman, Kerman, 761694111, Iran
  4. 4. Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  6. 6. Department of Chemistry, Bhupal Nobles’ University, Udaipur-313002, Rajasthan, India

Source: BMC Chemistry Published:2022


Abstract

Metal organic frameworks (MOFs) have received a lot of attention in the research community due to their unique physical properties, which make them ideal materials for targeted drug delivery systems. In this paper, we describe the synthesis of a non-toxic La-based MOF with 3,4-dihydroxycinnamic acid (3,4-DHCA) as a linker. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), nitrogen adsorption–desorption measurements, and X-ray powder diffraction (XRD) have all been used to characterize it thoroughly. The La-based MOF showed good biocompatibility with the human breast cancer cell line MDA-MB-468. The ability of 3,4-DHCA to treat MDA-MB-468 cells was confirmed by 40.35% cell viability with La-based MOF. Based on the findings, La-based MOF can be recommended as a promising candidate for anticancer delivery. © 2022, The Author(s).
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