Fabrication, Optimization, and in Vitro and in Vivo Characterization of Intra-Vitreal Implant of Budesonide Generally Made of Phbv

Fabrication, Optimization, and in Vitro and in Vivo Characterization of Intra-Vitreal Implant of Budesonide Generally Made of Phbv Publisher Pubmed

Mohtashami Z¹ ; Javar HA¹ ; Tehrani MR¹ ; Esfahani MR² ; Roohipour R² ; Aghajanpour L² ; Amoli FA² ; Vakilinezhad MA³ ; Dorkoosh FA^{1, 4}

Show Affiliations

1. Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Science, Tehran, Iran
2. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Pharmaceutical Science Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4. Medical Biomaterial Research Center, Tehran University of Medical Science, Tehran, Iran

Source: AAPS PharmSciTech Published:2020

Abstract

Drug delivery to vitreous in comparison with drug delivery to the other parts of the eye is complicated and challenging due to the existence of various anatomical and physiological barriers. Developing injectable intra-vitreal implant could be beneficial in this regard. Herein, poly(hydroxybutyrate-co-valerate) (PHBV) implants were fabricated and optimized using response surface method for budesonide (BZ) delivery. The acquired implants were characterized in regard to the stability of the ingredients during fabrication process, drug loading amount, and drug release pattern (in PBS-HA-A and in vitreous medium). According to this research and statistical analysis performed, first HV% (hydroxyvalerate) then molecular weight and ratio of PEG as pore former affect respectively release rate and burst strength of BZ with different coefficients. Drug release profile in rabbit eye correlated well with that of in vitro (R2 = 0.9861, p ˂ 0.0001). No significant changes were seen in ERG waves, intraocular pressure, and histological studies during the in vivo part of the project. Using 8% HV, 20% PEG/PHBV, and higher molecular weight PEG (i.e., 6000), the optimum formulation was achieved. Toxicity and biocompatibility of the optimized formulation, which were evaluated in vivo, indicated the suitability of design implant for intra-vitreal BZ delivery. [Figure not available: see fulltext.]. © 2020, American Association of Pharmaceutical Scientists.

2. Pharmaceutical Implants: Classification, Limitations and Therapeutic Applications, Pharmaceutical Development and Technology (2020)

3. Encapsulation: Controlled Drug Delivery, Principles of Biomaterials Encapsulation: Volume 2 (2023)

4. Recent Developments in Nanotechnology to Overcome the Challenges in Topical Drug Delivery to the Anterior and Posterior Segments of the Eye: Review Article, Tehran University Medical Journal (2015)

5. Preparation, Statistical Optimization and in Vitro Evaluation of Pramipexole Prolonged Delivery System Based on Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanoparticles, Journal of Drug Delivery Science and Technology (2018)

6. A Novel Approach for Development of Intraocular Biodegradable Ranibizumab Implant: A Solution for Stability of Protein Activity, Advanced Pharmaceutical Bulletin (2021)

7. Nanosuspensions in Ophthalmology: Overcoming Challenges and Enhancing Drug Delivery for Eye Diseases, International Journal of Pharmaceutics (2024)

8. Interleukin-6 Participation in Pathology of Ocular Diseases, Pathophysiology (2017)

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Farid Dorkoosh (3)

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Style	Citing Format
MLA	Mohtashami Z, et al.. "Fabrication, Optimization, and in Vitro and in Vivo Characterization of Intra-Vitreal Implant of Budesonide Generally Made of Phbv." AAPS PharmSciTech, vol. 21, no. 8, 2020, pp. -.
APA	Mohtashami Z, Javar HA, Tehrani MR, Esfahani MR, Roohipour R, Aghajanpour L, Amoli FA, Vakilinezhad MA, Dorkoosh FA (2020). Fabrication, Optimization, and in Vitro and in Vivo Characterization of Intra-Vitreal Implant of Budesonide Generally Made of Phbv. AAPS PharmSciTech, 21(8), -.
Chicago	Mohtashami Z, Javar HA, Tehrani MR, Esfahani MR, Roohipour R, Aghajanpour L, Amoli FA, Vakilinezhad MA, Dorkoosh FA. "Fabrication, Optimization, and in Vitro and in Vivo Characterization of Intra-Vitreal Implant of Budesonide Generally Made of Phbv." AAPS PharmSciTech 21, no. 8 (2020): -.
Harvard	Mohtashami Z et al. (2020) 'Fabrication, Optimization, and in Vitro and in Vivo Characterization of Intra-Vitreal Implant of Budesonide Generally Made of Phbv', AAPS PharmSciTech, 21(8), pp. -.
Vancouver	Mohtashami Z, Javar HA, Tehrani MR, Esfahani MR, Roohipour R, Aghajanpour L, et al.. Fabrication, Optimization, and in Vitro and in Vivo Characterization of Intra-Vitreal Implant of Budesonide Generally Made of Phbv. AAPS PharmSciTech. 2020;21(8):-.
BibTex	@article{ author = {Mohtashami Z and Javar HA and Tehrani MR and Esfahani MR and Roohipour R and Aghajanpour L and Amoli FA and Vakilinezhad MA and Dorkoosh FA}, title = {Fabrication, Optimization, and in Vitro and in Vivo Characterization of Intra-Vitreal Implant of Budesonide Generally Made of Phbv}, journal = {AAPS PharmSciTech}, volume = {21}, number = {8}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Mohtashami Z AU - Javar HA AU - Tehrani MR AU - Esfahani MR AU - Roohipour R AU - Aghajanpour L AU - Amoli FA AU - Vakilinezhad MA AU - Dorkoosh FA TI - Fabrication, Optimization, and in Vitro and in Vivo Characterization of Intra-Vitreal Implant of Budesonide Generally Made of Phbv JO - AAPS PharmSciTech VL - 21 IS - 8 SP - EP - PY - 2020 ER -

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