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Cellulose Acetate/Plerixafor Wound Dressings for Transplantation of Menstrual Blood Stem Cells: Potential Treatment Modality for Diabetic Wounds Publisher



Fan Y1 ; Zhi Y2 ; He M3 ; Ahmadzadeh B4 ; Rohani S5
Authors
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Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, Shaanxi Provincial People's Hospital, Xi'an, 710068, China
  2. 2. Department of Gynecology, Shandong Provincial Maternal and Child Health Care Hospital, Shandong, Jinan, 250000, China
  3. 3. Department of Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xi'an, 710068, China
  4. 4. Doctoral School of the University of Szczecin, Institute of Biology, University of Szczecin, Szczecin, 71-412, Poland
  5. 5. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Drug Delivery Science and Technology Published:2022


Abstract

In the current study, we used electrospun cellulose acetate scaffolds as a delivery vehicle for Plerixafor and menstrual blood stem cells (MenSCs) for diabetic wound healing applications. Cellulose acetate scaffolds were incorporated with 1.5% w/w Plerixafor and then seeded with 30000 MenSCs. The developed scaffolds were studied regarding their various physicochemical and biological properties. A wound healing assay was performed in the excisional diabetic wound rat model. Results showed that the cellulose acetate/Plerixafor/MenSCs group had a significantly higher wound healing rate than other groups. This group showed 93.72 ± 6.49% of wound size reduction, 45.66 ± 5.44 μm of epithelial thickness, and 46.25 ± 6.10% of collagen deposition at the end of the 14th day post-surgery. In addition, the wound healing function of these dressings was associated with a significant increase in the tissue expression level of the vascular endothelial growth factor gene (VEGF). The cellulose acetate/Plerixafor/MenSCs group significantly reduced the NFKβ gene expression. © 2022 Elsevier B.V.
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