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Recent Advances in Cellulose-Based Structures As the Wound-Healing Biomaterials: A Clinically Oriented Review Publisher



Abazari MF1 ; Gholizadeh S2, 3 ; Karizi SZ4 ; Birgani NH5 ; Abazari D6, 7 ; Paknia S8 ; Derakhshankhah H9 ; Allahyari Z2, 3 ; Amini SM10 ; Hamidi M11 ; Delattre C12, 13
Authors
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Authors Affiliations
  1. 1. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, 19987-11111, Iran
  2. 2. Department of Biomedical Engineering, Rochester Institute of Technology, 160 Lomb Memorial Drive, Rochester, 14623, NY, United States
  3. 3. Microsystems Engineering, Rochester Institute of Technology, Rochester, 14623, NY, United States
  4. 4. Department of Biology, Varamin Pishva Branch, Islamic Azad University, Varamin, 16517-16151, Iran
  5. 5. Department of Biology, Faculty of Science and Research, Islamic Azad University, Tehran, 19558-65143, Iran
  6. 6. Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, V6T 1X7, BC, Canada
  7. 7. Brain Research Centre, University of British Columbia, Vancouver, V6T 1X7, BC, Canada
  8. 8. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, 67158-47141, Iran
  9. 9. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, 67158-47141, Iran
  10. 10. Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, 14496-14535, Iran
  11. 11. Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, 44771-66595, Iran
  12. 12. Universite Clermont Auvergne, Clermont Auvergne INP, CNRS, Institut Pascal, Clermont-Ferrand, 63000, France
  13. 13. Institut Universitaire de France (IUF), 1 rue Descartes, Paris, 75005, France

Source: Applied Sciences (Switzerland) Published:2021


Abstract

Application of wound-healing/dressing biomaterials is amongst the most promising approaches for wound repair through protection from pathogen invasion/contamination, maintaining moisture, absorbing exudates, modulating inflammation, and facilitating the healing process. A wide range of materials are used to fabricate wound-healing/dressing biomaterials. Active wound-healing/dressings are next-generation alternatives for passive biomaterials, which provide a physical barrier and induce different biological activities, such as antibacterial, antioxidant, and prolifera-tive effects. Cellulose-based biomaterials are particularly promising due to their tunable physical, chemical, mechanical, and biological properties, accessibility, low cost, and biocompatibility. A thor-ough description and analysis of wound-healing/dressing structures fabricated from cellulose-based biomaterials is discussed in this review. We emphasize and highlight the fabrication methods, applied bioactive molecules, and discuss the obtained results from in vitro and in vivo models of cellulose-based wound-healing biomaterials. This review paper revealed that cellulose-based bio-materials have promising potential as the wound-dressing/healing materials and can be integrated with various bioactive agents. Overall, cellulose-based biomaterials are shown to be effective and sophisticated structures for delivery applications, safe and multi-customizable dressings, or grafts for wound-healing applications. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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