Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles

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Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles Publisher Pubmed

Mahmoudi M^{1, 2} ; Sheibani S³ ; Milani AS⁴ ; Rezaee F^{5, 6} ; Gauberti M⁷ ; Dinarvand R¹ ; Vali H³

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1. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Division of Cardiovascular Medicine, School of Medicine, Stanford University, Stanford, CA, United States
3. Department of Anatomy and Cell Biology, Facility for Electron Microscopy Research, McGill University, Montreal, H3A0C7, QC, Canada
4. School of Engineering, University of British Columbia, Okanagan Campus, Kelowna, BC, Canada
5. Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
6. Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands
7. Inserm UMR-S 919, Serine Proteases and Pathophysiology of the Neurovascular Unit, Universite de Caen Basse-Normandie, Caen Cedex, France

Source: Nanomedicine Published:2015

Abstract

Aims: We aimed to investigate the physicochemical effects of superparamagnetic iron oxide nanoparticles (SPIONs) on the composition of the protein corona and their correspondence toxicological issues. Materials & methods: SPIONs of different sizes and surface charges were exposed to fetal bovine serum. The structure/composition and biological effects of the protein corona-SPION complexes were probed. Results & discussion: The affinity and level of adsorption of specific proteins is strongly dependent on the size and surface charge of the SPIONs. In vivo experiments on the mouse blood-brain barrier model revealed that nontargeted SPIONs containing specific proteins will enter the brain endothelial barrier cells. Conclusion: Some commercially available nanoparticles used for target-specific applications may have unintended uptake in the body (e.g., brain tissue) with potential cytotoxity. © 2015 Future Medicine Ltd.

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Style	Citing Format
MLA	Mahmoudi M, et al.. "Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles." Nanomedicine, vol. 10, no. 2, 2015, pp. 215-226.
APA	Mahmoudi M, Sheibani S, Milani AS, Rezaee F, Gauberti M, Dinarvand R, Vali H (2015). Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles. Nanomedicine, 10(2), 215-226.
Chicago	Mahmoudi M, Sheibani S, Milani AS, Rezaee F, Gauberti M, Dinarvand R, Vali H. "Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles." Nanomedicine 10, no. 2 (2015): 215-226.
Harvard	Mahmoudi M et al. (2015) 'Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles', Nanomedicine, 10(2), pp. 215-226.
Vancouver	Mahmoudi M, Sheibani S, Milani AS, Rezaee F, Gauberti M, Dinarvand R, et al.. Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles. Nanomedicine. 2015;10(2):215-226.
BibTex	@article{ author = {Mahmoudi M and Sheibani S and Milani AS and Rezaee F and Gauberti M and Dinarvand R and Vali H}, title = {Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles}, journal = {Nanomedicine}, volume = {10}, number = {2}, pages = {215-226}, year = {2015} }
RIS	TY - JOUR AU - Mahmoudi M AU - Sheibani S AU - Milani AS AU - Rezaee F AU - Gauberti M AU - Dinarvand R AU - Vali H TI - Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles JO - Nanomedicine VL - 10 IS - 2 SP - 215 EP - 226 PY - 2015 ER -

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