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Covid-19 Prevention and Treatment by Targeting Proteins: An Experience to Fight Emerging Diseases Publisher Pubmed



Zare H1 ; Farkhondeh T2 ; Bakherad H3 ; Sharifi H4 ; Shirzeyli MH5 ; Samarghandian S6 ; Ghasemi F7, 8
Authors
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Authors Affiliations
  1. 1. Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  2. 2. Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran
  3. 3. Department of Pharmaceutical Biotechnology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Molecular Medicine, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  5. 5. Department of Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran
  7. 7. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
  8. 8. Department of Medical Biotechnology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran

Source: Current Molecular Medicine Published:2024


Abstract

The coronavirus disease 2019 (Covid-19) pandemic has been considered a major threat to human health. Effective therapeutic approaches are urgently required. Spike protein and the Angiotensin-converting enzyme 2 (ACE2) receptors have critical roles in SARS-CoV-2 infection. As a result, these two proteins are considered potential targets for the development of a wide variety of biotherapeutics and vaccines for controlling Covid-19. The fusion proteins have desirable medicinal properties, including high serum half-life, stability, and solubility in the body. Moreover, other Fc-fusion proteins used to treat other diseases have no known side effects. These Fc-fusion proteins are valuable biopharmaceuticals and have been proposed as therapeutic candidates for the treatment and prevention of Covid-19 owing to their potential therapeutic benefits. © 2024 Bentham Science Publishers.
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3. Fcγ1 Fragment of Igg1 As a Powerful Affinity Tag in Recombinant Fc-Fusion Proteins: Immunological, Biochemical and Therapeutic Properties, Critical Reviews in Biotechnology (2017)
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