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Naringin-Loaded Poly(Ε-Caprolactone)/Gelatin Electrospun Mat As a Potential Wound Dressing: In Vitro and in Vivo Evaluation Publisher



Salehi M1 ; Vaez A2 ; Naserinosar M1 ; Farzamfar S3 ; Ai A4 ; Ai J2 ; Tavakol S5 ; Khakbiz M6 ; Ebrahimibarough S2
Authors
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Authors Affiliations
  1. 1. Tissue Engineering and Stem Cell Research Center, Shahroud University of Medical Sciences, Shahroud, 3613773955, Iran
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  3. 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  4. 4. School of Medicine, Tehran University of Medical Sciences, Tehran, 141556447, Iran
  5. 5. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, 354-14665, Iran
  6. 6. Division of Biomedical Engineering, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, 143951561, Iran

Source: Fibers and Polymers Published:2018


Abstract

In the present study, naringin, a flavonoid isolated from the grape and citrus fruit species, was incorporated with poly(ε-caprolactone)/gelatin composite mats in order to develop a potential wound dressing. The composite mats were prepared by electrospinning of poly(ε-caprolactone)/gelatin (1:1 (w/w)) solution incorporated with 1.50 %, 3 % and 6 % (w/w) of naringin. The electrospun mats were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile properties, drug release, cellular response and in vivo wound healing activity. The study showed that after 2 weeks, the full-thickness excisional wounds of Wistar rats treated with the naringin-loaded dressings achieved a wound closure of higher than 94 % and the dressing containing 6 % (w/w) naringin had almost 100 % wound closure. The sterile gauze, as the control group, showed nearly 86 % of wound closure after this period of time. Our results provided evidence that supports the possible applicability of naringin-loaded wound dressing for successful wound treatment. © 2018, The Korean Fiber Society and Springer Science+Business Media B.V., part of Springer Nature.