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Cerium Oxide Nanoparticle-Containing Poly (Ε-Caprolactone)/Gelatin Electrospun Film As a Potential Wound Dressing Material: In Vitro and in Vivo Evaluation Publisher Pubmed



Naserinosar M1 ; Farzamfar S2 ; Sahrapeyma H3 ; Ghorbani S4 ; Bastami F5 ; Vaez A1 ; Salehi M6
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  2. 2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  3. 3. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, 1477893855, Iran
  4. 4. Department of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran, 14115111, Iran
  5. 5. Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, 1983969411, Iran
  6. 6. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, 3613773955, Iran

Source: Materials Science and Engineering C Published:2017


Abstract

In the present study, cerium oxide (CeO2) nanoparticles were incorporated into poly (ε-caprolactone)/gelatin films in order to develop a potential wound dressing material. The wound dressings were prepared by electrospinning of poly (ε-caprolactone)/gelatin (1:1 (w/w)) solutions containing 1.50%, 3% and 6% (w/w) CeO2 nanoparticles. The electrospun films were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile strength and cellular response. The film containing 1.50% CeO2 nanoparticles was chosen as the optimal dressing for the in vivo study on full-thickness excisional wounds of rats. The study showed that after 2 weeks, the wounds treated with the CeO2 nanoparticle-containing dressing achieved a significant closure to nearly 100% compared with the sterile gauze with the nearly 63% of wound closure. Our results provided evidence supporting the possible applicability of CeO2 nanoparticle-containing wound dressing for a successful wound treatment. © 2017
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