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Autophagy in Spinal Cord Injury: A Double- Edged Sword in Preclinical Studies of Synthetic and Natural Compounds Publisher



T Mokhtari TAHMINEH ; F Majidi FARZANEH ; F Sheikhbahaei FATEMEH ; Pb Shahreza Parvaneh BEHI ; Mp Poorhassan Mahnaz POUR
Authors

Source: Published:2025


Abstract

Autophagy is a crucial cellular process involved in spinal cord injury (SCI) patho-physiology. It can protect neural tissues by removing damaged cellular components, thereby promoting recovery. However, excessive autophagy may lead to neuronal apoptosis, inflammation, and disrupted cellular balance. This chapter explores the balance between autophagic activity and cellular health, emphasizing the need for precise regulation to harness autophagy's therapeutic potential. Recent studies highlight how autophagy interacts with mitochondrial dysfunction, reactive oxygen species, and inflammatory responses in SCI. Moreover, it discusses how natural compounds and nutraceuticals can modulate autophagy, offering promising strategies for managing consequences of SCI. Understanding autophagy is vital for advancing therapeutic interventions in SCI. © 2025 Elsevier B.V., All rights reserved.
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