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New Epigenetic Players in Stroke Pathogenesis: From Non-Coding Rnas to Exosomal Non-Coding Rnas Publisher Pubmed



Mahjoubintehran M1, 2 ; Rezaei S1, 2 ; Jesmani A3 ; Birang N4 ; Morshedi K5 ; Khanbabaei H6 ; Khan H7 ; Piranviseh A8 ; Nejati M9 ; Aschner M10 ; Mirzaei H11
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Physical Medicine and Rehabilitation, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  6. 6. Medical Physics Department, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan
  8. 8. Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  10. 10. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10463, NY, United States
  11. 11. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Biomedicine and Pharmacotherapy Published:2021


Abstract

Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke. © 2021 The Authors
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