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Metabolic Syndrome and Risk of Stroke Publisher Pubmed



Roever L1 ; Resende ES1 ; Diniz ALD1 ; Penhasilva N1 ; Oconnell JL1 ; Gomes PFS1 ; Zanetti HR1, 2 ; Roerverborges AS1 ; Veloso FC1 ; Fidale TM1 ; Casellafilho A3 ; Dourado PMM3 ; Chagas ACP3, 4 ; Alihasanalsaegh S5 Show All Authors
Authors
  1. Roever L1
  2. Resende ES1
  3. Diniz ALD1
  4. Penhasilva N1
  5. Oconnell JL1
  6. Gomes PFS1
  7. Zanetti HR1, 2
  8. Roerverborges AS1
  9. Veloso FC1
  10. Fidale TM1
  11. Casellafilho A3
  12. Dourado PMM3
  13. Chagas ACP3, 4
  14. Alihasanalsaegh S5
  15. Reis PEO6
  16. De Melo Pinto R1
  17. Oliveira GBF7
  18. Avezum A7
  19. Neto M8
  20. Duraes A8
  21. Da Silva RMFL9
  22. Grande AJ10
  23. Denardi C11
  24. Lopes RD12
  25. Nerlekar N13
  26. Alizadeh S14
  27. Hernandez AV15
  28. Biondizoccai G16, 17
Show Affiliations
Authors Affiliations
  1. 1. Federal University of Uberlandia, Department of Clinical Research, Master in Health Sciences, Uberlandia, Minas Gerais, Brazil
  2. 2. Heart Institute (InCor), Master Institute of Education President Antonio Carlos, Department of Clinical Research, IMEPAC, Araguari, Brazil
  3. 3. HCFMUSP-University of Sao Paulo Medical School, Department of Cardiology, Sao Paulo, Brazil
  4. 4. Faculty of Medicine ABC, Department of Cardiology, Santo-Andre, Brazil
  5. 5. Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Department of Cardiology, Yazd, Iran
  6. 6. Department of Specialized and General Surgery, Fluminense Federal University, Rio de Janeiro, Brazil
  7. 7. Dante Pazzanese Institute of Cardiology, Department of Clinical Research, Sao Paulo, Brazil
  8. 8. Graduate Program in Medicine and Health, Department of Heath and Sciences, Federal University of Bahia, Brazil
  9. 9. Federal University of Minas Gerais, Department of Cardiology, MG, Brazil
  10. 10. Federal University of Mato Grosso, MT, Department of Medicine, Brazil
  11. 11. FOP Unicamp, Department of Clinical Research, Brazil
  12. 12. Division of Cardiology, Duke University Medical Center, Department of Clinical Research, Durham, NC, United States
  13. 13. Monash Cardiovascular Research Centre and Monash Heart, Department of Cardiology, Clayton, VIC, Australia
  14. 14. Tehran University of Medical Sciences, Department of Medicine, Iran
  15. 15. University of Connecticut/Hartford Hospital Evidence-Based Practice Center, Department of Comparative Effectiveness and Outcomes Research Health Outcomes, CT, Hartford, United States
  16. 16. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
  17. 17. Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli, Italy

Source: Medicine (United States) Published:2018


Abstract

Introduction: The metabolic syndrome is composed of several cardiovascular risk factors and has a high prevalence throughout the world. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between metabolic syndrome and stroke. The aim of this study is to examine this association of metabolic syndrome with stroke in different ages and sex. Methods and analysis: The update systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (i.e., PubMed, EMBASE, Web of Science, and Google Scholar. Studies that examined the association between metabolic syndrome and stroke, had a longitudinal or prospective cohort design, were conducted among in adults aged 40 to 70 years, provided sufficient data for calculating ORs or relative risk with a 95% CI, were published as original articles written in English or other languages, and have been published until December 2017 will be included. Study selection, data collection, quality assessment, and statistical syntheses will be conducted based on discussions among investigators. Ethicsanddissemination: Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. The findings from this study could be useful for assessing metabolic syndrome risk factors in stroke, and determining approaches for prevention of stroke in the future. Abbreviations: CIs = confidence intervals, HDL = high-density lipoprotein, LDL = low-density lipoprotein, MD = mean difference, MetS = metabolic syndrome, RR = risk ratio, WC = waist circumference. Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.