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Current Treatments and Therapeutic Options for Covid-19 Patients: A Systematic Review Publisher Pubmed



Mehraeen E1 ; Najafi Z2 ; Hayati B3 ; Javaherian M4 ; Rahimi S3 ; Dadras O5 ; Seyedalinaghi S2 ; Ghadimi M6 ; Sabatier JM7
Authors
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Authors Affiliations
  1. 1. Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran
  2. 2. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Environmental Health, Khalkhal University of Medical Sciences, Khalkhal, Iran
  4. 4. Department of Physiotherapy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Public Health, Walailak University, 222 Thaiburi Thasala, Nakhon Si Thammarat, Thailand
  6. 6. Postdoctoral Fellow, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  7. 7. Institut de Neuro-physiopathologie (INP), Faculte de Pharmacie, Universite Aix-Marseille, UMR 7051, 27 Bd Jean Moulin, Marseille Cedex, 13385, France

Source: Infectious Disorders - Drug Targets Published:2022


Abstract

Introduction: COVID-19 is the third rising epidemic in the 21st century that quickly turned into a worldwide pandemic. Many clinical studies have been achieved to investigate treatments to con-front COVID-19. Therefore, we conducted a systematic review to describe the recent treatment strate-gies to treat COVID-19 patients. Methods: A systematic search was performed in the databases of PubMed, Scopus, Embase, Science direct, Up to date, and Web of Science using the keywords of Coronavirus, COVID-19, SARS-CoV-2, Novel Coronavirus, 2019-nCoV, Treatment, Medicine, Therapy, Intervention, Drug, Medications, and Cure. All the relevant articles were collected from December 2019 to July 2020. Results: We included 58 studies including 38 articles (eleven reviews, ten editorial documents, three case reports, one mix method, one cohort study), and 19 published clinical trials. Review of studies showed that Lopinavir/Ritonavir (n=16), Remdesivir (n=13), Convalescent plasma (n=11), Chloroquine (n=11), Ribavirin (n=9), Hydroxychloroquine sulfate (n=8), Traditional Chinese Medicine (TCM) (n=8), and Arbidol (n=7), were the most frequently therapies used to treat COVID-19 patients. Conclusion: In the absence of definitive treatment protocols, recently proposed approaches have ap-peared to be an effective therapy for accelerating the recovery of COVID-19 patients. Some of these treatments may have been in the early stages of testing. However, future preclinical and clinical trials are warranted to validate findings. © 2022 Bentham Science Publishers.
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