Voltammetric Determination of Venlafaxine As an Antidepressant Drug Employing Gd 2 O 3 Nanoparticles Graphite Screen Printed Electrode Publisher



Beitollahi H¹ ; Jahani S² ; Tajik S² ; Ganjali MR^{3, 4} ; Faridbod F³ ; Alizadeh T⁵ Show Affiliations
Source: Journal of Rare Earths Published:2019

Abstract

Graphite screen printed electrode modified with Gd 2 O 3 nanoparticles (Gd 2 O 3 /SPE) was developed for the determination of venlafaxine (VF). The Gd 2 O 3 nanoparticles were thoroughly characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) analyses. To study the electrochemical behaviour of venlafaxine cyclic voltammetry (CV), chronoamperometry (CHA) and differential pulse voltammetry (DPV) were employed. These studies reveal that the oxidation of venlafaxine is facilitated at Gd 2 O 3 /SPE. After optimization of analytical conditions, analysis of venlafaxine using the modified electrode in 0.1 mol/L PBS (pH 7.0) demonstrates that the peak currents corresponding to venlafaxine vary linearly with its concentration in the range of 5.0 × 10 −6 – 9.0 × 10 −4 mol/L. The detection limit (S/N = 3) of 2.1 × 10 −7 mol/L is obtained for venlafaxine using DPV. The prepared modified electrode benefits from advantages such as simple preparation method, high sensitivity and low detection limit. Moreover, the evaluation of practical applicability of this proposed method is successful in the identification of venlafaxine in pharmaceutical formulations, urine and water samples. © 2018