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Mir-142-3P/5P Role in Cancer: From Epigenetic Regulation to Immunomodulation Publisher Pubmed



Zareifar P1 ; Ahmed HM2 ; Ghaderi P3 ; Farahmand Y4 ; Rahnama N5 ; Esbati R6 ; Moradi A7 ; Yazdani O6 ; Sadeghipour Y8
Authors
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Authors Affiliations
  1. 1. Golestan University of Medical Science, Golestan, Gorgan, Iran
  2. 2. Department of Pharmacy, Al-Noor University College, Nineveh, Iraq
  3. 3. Department of Biotechnology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
  4. 4. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Internal Medicine and Health Services, Semnan University of Medical Sciences, Semnan, Iran
  6. 6. Department of Medicine, Shahid Beheshti University, Tehran, Iran
  7. 7. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Cell Biochemistry and Function Published:2024


Abstract

MicroRNAs (miRNAs) play critical roles in cancer pathobiology, acting as regulators of gene expression and pivotal drivers of tumorigenesis. It is believed that miRNAs act through canonical mechanisms, involving the binding of mature miRNAs to target messenger RNAs (mRNAs) and subsequent repression of protein translation or degradation of target mRNAs. miR-142-3p/5p has been extensively studied and established as a key regulator in various malignancies. Recent discoveries have revealed miR-142-3p/5p serve as either oncogene or tumor suppressor in cancer. By targeting epigenetic factor and cancer-related signaling pathway, miR-142-3p/5p can regulate wide range of downstream genes. The immune modulatory role of miR-142-3p/5p has been shown in various cancers, which provides significant insight into immunosuppression and tumor escape from the immune response. Exosomes with miR-142-3p/5p facilitate cell communication and can affect cancer cell behavior, offering potential therapeutic, and diagnosis applications in cancer therapy. In this review, for the first time, we comprehensively summarize the current knowledge regarding mentioned functions of miR-142-3p/5p in cancer pathobiology. © 2024 John Wiley & Sons Ltd.
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