Cellular Uptake of Nanoparticles: Journey Inside the Cell Publisher Pubmed



Behzadi S¹ ; Serpooshan V² ; Tao W¹ ; Hamaly MA³ ; Alkawareek MY⁴ ; Dreaden EC⁵ ; Brown D^{6, 7} ; Alkilany AM⁴ ; Farokhzad OC^{1, 8} ; Mahmoudi M^{1, 9} Show Affiliations
Source: Chemical Society Reviews Published:2017

Abstract

Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body in myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at the cellular and subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell-cell communication, and modulate cell structure in a manner dictated largely by phenomena at the nano-bio interface. Recent advances in chemical synthesis have yielded new nanoscale materials with precisely defined biochemical features, and emerging analytical techniques have shed light on nuanced and context-dependent nano-bio interactions within cells. In this review, we provide an objective and comprehensive account of our current understanding of the cellular uptake of NPs and the underlying parameters controlling the nano-cellular interactions, along with the available analytical techniques to follow and track these processes. © 2017 The Royal Society of Chemistry.