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Epicardial Fstl1 Reconstitution Regenerates the Adult Mammalian Heart Publisher Pubmed



Wei K1, 2 ; Serpooshan V3 ; Hurtado C1, 2 ; Diezcunado M1, 2, 3 ; Zhao M3 ; Maruyama S4 ; Zhu W1, 2 ; Fajardo G3 ; Noseda M5 ; Nakamura K4 ; Tian X6 ; Liu Q6 ; Wang A3 ; Matsuura Y3 Show All Authors
Authors
  1. Wei K1, 2
  2. Serpooshan V3
  3. Hurtado C1, 2
  4. Diezcunado M1, 2, 3
  5. Zhao M3
  6. Maruyama S4
  7. Zhu W1, 2
  8. Fajardo G3
  9. Noseda M5
  10. Nakamura K4
  11. Tian X6
  12. Liu Q6
  13. Wang A3
  14. Matsuura Y3
  15. Bushway P1, 2
  16. Cai W1, 2
  17. Savchenko A1, 2
  18. Mahmoudi M3, 7
  19. Schneider MD5
  20. Van Den Hoff MJB8
  21. Butte MJ3
  22. Yang PC3
  23. Walsh K4
  24. Zhou B6, 9
  25. Bernstein D3
  26. Mercola M1, 2
  27. Ruizlozano P3

Source: Nature Published:2015


Abstract

The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1). Epicardial Fstl1 declines following myocardial infarction and is replaced by myocardial expression. Myocardial Fstl1 does not promote regeneration, either basally or upon transgenic overexpression. Application of the human Fstl1 protein (FSTL1) via an epicardial patch stimulates cell cycle entry and division of pre-existing cardiomyocytes, improving cardiac function and survival in mouse and swine models of myocardial infarction. The data suggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration would be an effective way to reverse myocardial death and remodelling following myocardial infarction in humans. © 2015 Macmillan Publishers Limited.
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