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Micelle-Based Nanoparticles With Stimuli-Responsive Properties for Drug Delivery Publisher



Maboudi AH3 ; Lotfipour MH4 ; Rasouli M1, 2 ; Azhdari MH3 ; Macloughlin R5, 6, 7 ; Bekeschus S8, 9 ; Doroudian M3
Authors
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Authors Affiliations
  1. 1. Plasma Medicine Group, Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Jalale-Al-Ahmad Ave, Tehran, 1411713137, Iran
  2. 2. Department of Physics, Kharazmi University, 49 Dr. Mofatteh Ave, Tehran, 15614, Iran
  3. 3. Department of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  4. 4. Department of Medical Genetics, School of Medicine, Babol University of Medical Sciences, Babol, Iran
  5. 5. Research and Development, Science and Emerging Technologies, Aerogen Limited, Galway Business Park, Galway, H91 HE94, Ireland
  6. 6. School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland
  7. 7. School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, D02 PN40, Ireland
  8. 8. ZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Str 2, Greifswald, 17489, Germany
  9. 9. Clinic and Policlinic for Dermatology and Venerology, Rostock University Medical Center, Strempelstr. 13, Rostock, 18057, Germany

Source: Nanotechnology Reviews Published:2024


Abstract

Cancer treatment often causes adverse effects and toxicity, as chemotherapy drugs affect both cancerous and healthy cells. Scientists seek to target tumor cells specifically and minimize harm to normal cells. Smart nanoparticles (NPs) are a modern technique that can release drugs when triggered by internal or external stimuli, such as temperature, pH, ultrasound, etc. This review covers stimuli-responsive micelle-based nanoparticles (SRM-NPs), a promising drug delivery platform that can enhance drug efficacy and reduce toxicity. It discusses the recent developments and applications of SRM-NPs, their responsiveness to different stimuli, and their potential to overcome drug resistance and adaptive responses. It also addresses the challenges and issues related to their stability, reproducibility, biocompatibility, safety, and optimization. The study concludes that SRM-NPs have great potential for drug delivery, but more research and development are needed to improve their clinical utility. © 2024 the author(s), published by De Gruyter.
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