Micelle-Based Nanoparticles With Stimuli-Responsive Properties for Drug Delivery Publisher



Maboudi AH³ ; Lotfipour MH⁴ ; Rasouli M^{1, 2} ; Azhdari MH³ ; Macloughlin R^{5, 6, 7} ; Bekeschus S^{8, 9} ; Doroudian M³
Source: Nanotechnology Reviews Published:2024

Abstract

Cancer treatment often causes adverse effects and toxicity, as chemotherapy drugs affect both cancerous and healthy cells. Scientists seek to target tumor cells specifically and minimize harm to normal cells. Smart nanoparticles (NPs) are a modern technique that can release drugs when triggered by internal or external stimuli, such as temperature, pH, ultrasound, etc. This review covers stimuli-responsive micelle-based nanoparticles (SRM-NPs), a promising drug delivery platform that can enhance drug efficacy and reduce toxicity. It discusses the recent developments and applications of SRM-NPs, their responsiveness to different stimuli, and their potential to overcome drug resistance and adaptive responses. It also addresses the challenges and issues related to their stability, reproducibility, biocompatibility, safety, and optimization. The study concludes that SRM-NPs have great potential for drug delivery, but more research and development are needed to improve their clinical utility. © 2024 the author(s), published by De Gruyter.