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Existing Antiviral Options Against Sars-Cov-2 Replication in Covid-19 Patients Publisher Pubmed



Ghanbari R1 ; Teimoori A2 ; Sadeghi A1 ; Mohamadkhani A1 ; Rezasoltani S3 ; Asadi E4 ; Jouyban A5 ; Sumner SCJ6
Authors
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Authors Affiliations
  1. 1. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Science, Tehran, 1411713135, Iran
  2. 2. Department of Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, 65178-38678, Iran
  3. 3. Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, 1985717411, Iran
  4. 4. Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, S7N 5B4, SK, Canada
  5. 5. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 5166/1573, Iran
  6. 6. Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, 28081, NC, United States

Source: Future Microbiology Published:2020


Abstract

COVID-19 caused by SARS-CoV-2, is an international concern. This infection requires urgent efforts to develop new antiviral compounds. To date, no specific drug in controlling this disease has been identified. Developing the new treatment is usually time consuming, therefore using the repurposing broad-spectrum antiviral drugs could be an effective strategy to respond immediately. In this review, a number of broad-spectrum antivirals with potential efficacy to inhibit the virus replication via targeting the virus spike protein (S protein), RNA-dependent RNA polymerase (RdRp), 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro) that are critical in the pathogenesis and life cycle of coronavirus, have been evaluated as possible treatment options against SARS-CoV-2 in COVID-19 patients. © 2021 Future Medicine Ltd
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