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Autophagy Role As a Double-Edged Sword in Anesthesiology and Critical Care Publisher



Zandi M1 ; Fazeli M2 ; Ghadimi P3 ; Soltani S1 ; Jalilian FA2 ; Shahani AB5 ; Behboudi E4 ; Pourhossein B2
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  4. 4. Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cellular and Molecular Anesthesia Published:2021


Abstract

Autophagy is a conserved lysosomal degradation pathway that breaks down cytoplasmic components and is essential for host cellular immune response. The activity of autophagy at a basic rate is crucial for homeostasis. Autophagy has emerged in recent years as a major mechanism in many neurodegenerative diseases. The regulation of microbial infections and inflammatory responses can be significantly influenced by autophagic modulators. In this study, we explain the autophagy role as a double-edged sword in anesthesiology and critical care. Future studies should focus on investigating the molecular mechanism of interplay between pathogen-host-autophagy and on studying whether autophagy inducers/inhibitors can exert suitable modulatory immunomodulatory effects. Potential organ protection through autophagy pathways might be an advantage in patients undergoing anesthesia and/or needing critical care. © 2021 Journal of Cellular and Molecular Anesthesia. All rights reserved.
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