Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work?

Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work? Publisher Pubmed

Farjadian F¹ ; Moghoofei M² ; Mirkiani S³ ; Ghasemi A⁴ ; Rabiee N⁵ ; Hadifar S⁶ ; Beyzavi A⁷ ; Karimi M^{8, 9, 10} ; Hamblin MR^{10, 11, 12}

Show Affiliations

1. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2. Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
3. Biomaterials Laboratory, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
4. Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
5. Department of Chemistry, Shahid Beheshti University, Tehran, Iran
6. Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
7. Koch institute of MIT, 500 Main Street, Cambridge, MA, United States
8. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
9. Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
10. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, MA, United States
11. Department of Dermatology, Harvard Medical School, Boston, 02115, MA, United States
12. Harvard-MIT Division of Health Sciences and Technology, Cambridge, 02139, MA, United States

Source: Biotechnology Advances Published:2018

Abstract

Drug delivery is a rapidly growing area of research motivated by the nanotechnology revolution, the ideal of personalized medicine, and the desire to reduce the side effects of toxic anti-cancer drugs. Amongst a bewildering array of different nanostructures and nanocarriers, those examples that are fundamentally bio-inspired and derived from natural sources are particularly preferred. Delivery of vaccines is also an active area of research in this field. Bacterial cells and their components that have been used for drug delivery, include the crystalline cell-surface layer known as “S-layer” bacterial ghosts, bacterial outer membrane vesicles, and bacterial products or derivatives (e.g. spores, polymers, and magnetic nanoparticles). Considering the origin of these components from potentially pathogenic microorganisms, it is not surprising that they have been applied for vaccines and immunization. The present review critically summarizes their applications focusing on their advantages for delivery of drugs, genes, and vaccines. © 2018 Elsevier Inc.

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Style	Citing Format
MLA	Farjadian F, et al.. "Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work?." Biotechnology Advances, vol. 36, no. 4, 2018, pp. 968-985.
APA	Farjadian F, Moghoofei M, Mirkiani S, Ghasemi A, Rabiee N, Hadifar S, Beyzavi A, Karimi M, Hamblin MR (2018). Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work?. Biotechnology Advances, 36(4), 968-985.
Chicago	Farjadian F, Moghoofei M, Mirkiani S, Ghasemi A, Rabiee N, Hadifar S, Beyzavi A, Karimi M, Hamblin MR. "Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work?." Biotechnology Advances 36, no. 4 (2018): 968-985.
Harvard	Farjadian F et al. (2018) 'Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work?', Biotechnology Advances, 36(4), pp. 968-985.
Vancouver	Farjadian F, Moghoofei M, Mirkiani S, Ghasemi A, Rabiee N, Hadifar S, et al.. Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work?. Biotechnology Advances. 2018;36(4):968-985.
BibTex	@article{ author = {Farjadian F and Moghoofei M and Mirkiani S and Ghasemi A and Rabiee N and Hadifar S and Beyzavi A and Karimi M and Hamblin MR}, title = {Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work?}, journal = {Biotechnology Advances}, volume = {36}, number = {4}, pages = {968-985}, year = {2018} }
RIS	TY - JOUR AU - Farjadian F AU - Moghoofei M AU - Mirkiani S AU - Ghasemi A AU - Rabiee N AU - Hadifar S AU - Beyzavi A AU - Karimi M AU - Hamblin MR TI - Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work? JO - Biotechnology Advances VL - 36 IS - 4 SP - 968 EP - 985 PY - 2018 ER -

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