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Interleukin-2 and Interferon-Gamma Single Nucleotide Polymorphisms in Iranian Patients With Chronic Heart Failure



Mahmoudi MJ1 ; Harsini S2 ; Farhadi E3 ; Hedayat M4 ; Taghvaei M2 ; Mahmoudi M5 ; Sadr M2 ; Esfahanian N2 ; Nematipour E6 ; Nourijelyani K7 ; Amirzargar AA2, 8 ; Rezaei N2, 8, 9, 10
Authors
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Authors Affiliations
  1. 1. Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Hematology, Faculty of Allied Medical Science, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States
  5. 5. Faculty of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Epidemiology and Biostatistics, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Avicenna Journal of Medical Biotechnology Published:2018

Abstract

Background: Inflammatory cytokines have been known to be associated with Chronic Heart Failure (CHF). Given the importance of cytokines in the context of the failing heart, the prevalence of Interleukin-2 (IL-2) and Interferon-gamma (IFN-γ) polymorphisms was studied in patients with CHF due to ischemic heart disease in a case-control study. Methods: Fifty-six Iranian patients with CHF were enrolled in this study as the case group and compared with 139 healthy subjects, using polymerase chain reaction with sequence-specific primers method, so as to determine the frequency of alleles, genotypes and haplotypes of IFN-γ (+874 A/T) and IL-2 (-330 G/T, +166 G/T) SNPs. Results: The GG genotype at IL-2-330 in patients with CHF was significantly overrepresented in comparison with the control group (p=0.013). Such a positive genotypic association was also observed for IL-2 +166/TT (p=0.022). Meanwhile, the GT genotype frequency at IL-2-330/GT in the patient group was significantly lower than the one in healthy controls (p=0.049). No significant association was detected between the IFN-γ gene polymorphisms and individuals’ susceptibility to CHF. Conclusion: Certain genotypes in IL-2 gene were overrepresented in patients with CHF, which could render individuals more vulnerable to this disease. © 2018, Avicenna Journal of Medical Biotechnology. All rights reserved.
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