Lichenochemical Analysis and Cytotoxicity of Diploschistes Ocellatus (Fr.) Norman

Lichenochemical Analysis and Cytotoxicity of Diploschistes Ocellatus (Fr.) Norman Publisher

Eftekhari M^{1, 2} ; Sohrabi M³ ; Kahnamoei MB⁴ ; Oskou F⁵ ; Abdshahzadeh H⁵ ; Mansourian M^{6, 7} ; Saeedi M^{5, 8} ; Ardekani MRS^{5, 9} ; Akbarzadeh T⁵ ; Khanavi M^{5, 9, 10}

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1. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2. Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3. Iranian Research Organization for Science and Technology (IROST), Tehran, Iran
4. Department of Pharmacognosy, Faculty of Pharmacy, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran
5. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
6. Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
7. Department of Pharmacology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
8. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
9. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
10. Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada

Source: Research Journal of Pharmacognosy Published:2023

Abstract

Background and objectives: Diploschistes ocellatus (Fr.) Norman is a valuable lichen possessing various biological properties which has been traditionally used by indigenous people in southwest of Iran in the treatment of different disorders. The aim of the current study was to evaluate cytotoxicity of different fractions of D. ocellatus against breast cancer cell lines through MTT assay, as well as lichenochemical analysis of the most potent fraction. Also, ducking study was performed to investigate the isolated compounds-protein interactions. Methods: In this work, aqueous, acetone, chloroform, ethyl acetate, and methanol fractions of D. ocellatus were evaluated against three breast cancer cell lines (MCF-7, T-47D, and MDA-MB-231) via MTT assay. Furthermore, docking was performed using the routine method and default parameters of the AutoDock 4.2 software. Results: The acetone fraction depicted the most potent cytotoxicity and was candidate for lichenochemical analysis, leading to the isolation and identification of stictic acid and 2-(7'-hydroxy-3,5,6,8-tetramethyl-9-oxooxonan-2-yl) propanoic acid. Docking study of isolated compounds based on the inhibition of survivin, revealed desired interactions with that of amino acid residues. Conclusion: Based on the obtained results, D. ocellatus can be considered as a natural source of biologically active compounds and complementary studies are in high demand. © 2023. Open access.

2. Anti-Helicobacter Pylori Compounds From Oliveria Decumbens Vent. Through Urease Inhibitory In-Vitro and In-Silico Studies, Iranian Journal of Pharmaceutical Research (2021)

3. Extraction and Identification of Two Flavonoids in Phlomoides Hyoscyamoides As an Endemic Plant of Iran: The Role of Quercetin in the Activation of the Glutathione Peroxidase, the Improvement of the Hydroxyproline and Protein Oxidation in Bile Duct-Ligated Rats, Current Computer-Aided Drug Design (2020)

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Mohammad Reza Shams-Ardekani (2)

Mahnaz Khanavi (2)

Style	Citing Format
MLA	Eftekhari M, et al.. "Lichenochemical Analysis and Cytotoxicity of Diploschistes Ocellatus (Fr.) Norman." Research Journal of Pharmacognosy, vol. 10, no. 2, 2023, pp. 1-8.
APA	Eftekhari M, Sohrabi M, Kahnamoei MB, Oskou F, Abdshahzadeh H, Mansourian M, Saeedi M, Ardekani MRS, Akbarzadeh T, Khanavi M (2023). Lichenochemical Analysis and Cytotoxicity of Diploschistes Ocellatus (Fr.) Norman. Research Journal of Pharmacognosy, 10(2), 1-8.
Chicago	Eftekhari M, Sohrabi M, Kahnamoei MB, Oskou F, Abdshahzadeh H, Mansourian M, Saeedi M, Ardekani MRS, Akbarzadeh T, Khanavi M. "Lichenochemical Analysis and Cytotoxicity of Diploschistes Ocellatus (Fr.) Norman." Research Journal of Pharmacognosy 10, no. 2 (2023): 1-8.
Harvard	Eftekhari M et al. (2023) 'Lichenochemical Analysis and Cytotoxicity of Diploschistes Ocellatus (Fr.) Norman', Research Journal of Pharmacognosy, 10(2), pp. 1-8.
Vancouver	Eftekhari M, Sohrabi M, Kahnamoei MB, Oskou F, Abdshahzadeh H, Mansourian M, et al.. Lichenochemical Analysis and Cytotoxicity of Diploschistes Ocellatus (Fr.) Norman. Research Journal of Pharmacognosy. 2023;10(2):1-8.
BibTex	@article{ author = {Eftekhari M and Sohrabi M and Kahnamoei MB and Oskou F and Abdshahzadeh H and Mansourian M and Saeedi M and Ardekani MRS and Akbarzadeh T and Khanavi M}, title = {Lichenochemical Analysis and Cytotoxicity of Diploschistes Ocellatus (Fr.) Norman}, journal = {Research Journal of Pharmacognosy}, volume = {10}, number = {2}, pages = {1-8}, year = {2023} }
RIS	TY - JOUR AU - Eftekhari M AU - Sohrabi M AU - Kahnamoei MB AU - Oskou F AU - Abdshahzadeh H AU - Mansourian M AU - Saeedi M AU - Ardekani MRS AU - Akbarzadeh T AU - Khanavi M TI - Lichenochemical Analysis and Cytotoxicity of Diploschistes Ocellatus (Fr.) Norman JO - Research Journal of Pharmacognosy VL - 10 IS - 2 SP - 1 EP - 8 PY - 2023 ER -

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