A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative Stress, Cellular, and Molecular Mechanisms

A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative Stress, Cellular, and Molecular Mechanisms Publisher Pubmed

Golmohammadi M¹ ; Elmaghraby DA² ; Ramirezcoronel AA^{3, 4, 5, 6} ; Rakhimov N⁷ ; Mohammed SS⁸ ; Romeroparra RM⁹ ; Jawad MA¹⁰ ; Zamanian MY^{11, 12} ; Soltani A¹³ ; Taheri N¹⁴ ; Kianifar F¹⁵ ; Vousooghi N¹⁶

Show Affiliations

1. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1988873554, Iran
2. Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, 31982, Saudi Arabia
3. Health and Behavior Research Group (HBR), Psychometry and Ethology Laboratory, Catholic University of Cuenca, Azogues Campus Nursing Career, Cuenca, Ecuador
4. University of Palermo, Buenos Aires, Argentina
5. Research group in educational statistics, National University of Education, Cuenca, Ecuador
6. Epidemiology and Biostatistics Research Group, CES University, Medellin, Colombia
7. Department of Oncology, Samarkand State Medical University, Amir Temur Street 18, Samarkand, Uzbekistan
8. Department of Nursing, Al- Mustaqbal University College, Hillah, 51001, Iraq
9. General Studies, Universidad Continental, Lima, Peru
10. Al-Nisour University College, Baghdad, Iraq
11. Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, 6718773654, Iran
12. Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, 6718773654, Iran
13. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
14. School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
15. School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
16. Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755469, Iran

Source: Fundamental and Clinical Pharmacology Published:2023

Abstract

Bladder cancer (BC) is known as a prevalent genitourinary malignancy and has a significant mortality rate worldwide. Despite recent therapeutic approaches, the recurrence rate is high, highlighting the need for a new strategy to reduce the BC cell progression. Quercetin, a flavonoid compound, demonstrated promising anticancer properties and could be used in the management of various malignancies such as BC. This comprehensive review summarized quercetin's cellular and molecular mechanisms underlying anticancer activities. The study's findings indicated that quercetin prevents the proliferation of the human BC cell line, promotes apoptosis of BIU-87 cells, reduces the expression of p-P70S6K, and induces apoptosis by p-AMPK. Moreover, quercetin restricts tumor growth through the AMPK/mTOR cascade and prevents colony formation of human BC cells by triggering DNA damage. Studying this review article will help researchers better understand quercetin's functional role in the prevention and treatment of BC. © 2023 Societe Francaise de Pharmacologie et de Therapeutique.

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Style	Citing Format
MLA	Golmohammadi M, et al.. "A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative Stress, Cellular, and Molecular Mechanisms." Fundamental and Clinical Pharmacology, vol. 37, no. 5, 2023, pp. 900-909.
APA	Golmohammadi M, Elmaghraby DA, Ramirezcoronel AA, Rakhimov N, Mohammed SS, Romeroparra RM, Jawad MA, Zamanian MY, Soltani A, Taheri N, Kianifar F, Vousooghi N (2023). A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative Stress, Cellular, and Molecular Mechanisms. Fundamental and Clinical Pharmacology, 37(5), 900-909.
Chicago	Golmohammadi M, Elmaghraby DA, Ramirezcoronel AA, Rakhimov N, Mohammed SS, Romeroparra RM, Jawad MA, et al.. "A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative Stress, Cellular, and Molecular Mechanisms." Fundamental and Clinical Pharmacology 37, no. 5 (2023): 900-909.
Harvard	Golmohammadi M et al. (2023) 'A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative Stress, Cellular, and Molecular Mechanisms', Fundamental and Clinical Pharmacology, 37(5), pp. 900-909.
Vancouver	Golmohammadi M, Elmaghraby DA, Ramirezcoronel AA, Rakhimov N, Mohammed SS, Romeroparra RM, et al.. A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative Stress, Cellular, and Molecular Mechanisms. Fundamental and Clinical Pharmacology. 2023;37(5):900-909.
BibTex	@article{ author = {Golmohammadi M and Elmaghraby DA and Ramirezcoronel AA and Rakhimov N and Mohammed SS and Romeroparra RM and Jawad MA and Zamanian MY and Soltani A and Taheri N and Kianifar F and Vousooghi N}, title = {A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative Stress, Cellular, and Molecular Mechanisms}, journal = {Fundamental and Clinical Pharmacology}, volume = {37}, number = {5}, pages = {900-909}, year = {2023} }
RIS	TY - JOUR AU - Golmohammadi M AU - Elmaghraby DA AU - Ramirezcoronel AA AU - Rakhimov N AU - Mohammed SS AU - Romeroparra RM AU - Jawad MA AU - Zamanian MY AU - Soltani A AU - Taheri N AU - Kianifar F AU - Vousooghi N TI - A Comprehensive View on the Quercetin Impact on Bladder Cancer: Focusing on Oxidative Stress, Cellular, and Molecular Mechanisms JO - Fundamental and Clinical Pharmacology VL - 37 IS - 5 SP - 900 EP - 909 PY - 2023 ER -

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