Peroxidase Effect of Ce2(Wo4)3 Nanoparticles to Detection of Glucose As a Colorimetric Sensor Publisher



Alaei A¹ ; Hosseini M^{1, 2} ; Shokri E³ ; Ganjali MR^{4, 5}
Source: ChemistrySelect Published:2022

Abstract

Abnormal glucose level can cause irreversible damage, including diabetes. In this work, a sensor was designed that mimics the peroxidase property of the natural horseradish peroxidase (HRP). The proposed sensor detects the presence of glucose through the reduction of hydrogen peroxide (H2O2) and the oxidation of tetramethylbenzidine (TMB). This sensor shows linear behaviour in the range of 0.001–50 μM with a limit of detection down to 0.8 nM. In addition, a paper-based format of this sensing platform was performed which enables fast and sensitive detection and further reduces the expenses. In this method the linear behaviour of the sensor is between 0.005–40 μM and the detection limit is as low as 2.4 nM. The glucose detection in human saliva was also performed, showing an acceptable accuracy. Thus the sensor is practically suitable for the non-invasive detection of glucose. © 2022 Wiley-VCH GmbH.