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Gut Microbiota and Covid-19: A Systematic Review Publisher



Seyedalinaghi S1 ; Afzalian A2 ; Pashaei Z1 ; Varshochi S2 ; Karimi A2 ; Mojdeganlou H3 ; Mojdeganlou P4 ; Razi A2 ; Ghanadinezhad F5 ; Shojaei A1 ; Amiri A1 ; Dashti M6 ; Ghasemzadeh A6 ; Dadras O1, 7 Show All Authors
Authors
  1. Seyedalinaghi S1
  2. Afzalian A2
  3. Pashaei Z1
  4. Varshochi S2
  5. Karimi A2
  6. Mojdeganlou H3
  7. Mojdeganlou P4
  8. Razi A2
  9. Ghanadinezhad F5
  10. Shojaei A1
  11. Amiri A1
  12. Dashti M6
  13. Ghasemzadeh A6
  14. Dadras O1, 7
  15. Mehraeen E8
  16. Afsahi AM9
Show Affiliations
Authors Affiliations
  1. 1. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathology, Urmia University of Medical Sciences, Urmia, Iran
  4. 4. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Shahid Chamran University of Ahvaz, Ahvaz, Iran
  6. 6. Department of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
  8. 8. Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran
  9. 9. Department of Radiology, University of California, San Diego (UCSD), CA, United States

Source: Health Science Reports Published:2023


Abstract

Background and Aims: Alteration in humans' gut microbiota was reported in patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The gut and upper respiratory tract (URT) microbiota harbor a dynamic and complex population of microorganisms and have strong interaction with host immune system homeostasis. However, our knowledge about microbiota and its association with SARS-CoV-2 is still limited. We aimed to systematically review the effects of gut microbiota on the SARS-CoV-2 infection and its severity and the impact that SARS-CoV-2 could have on the gut microbiota. Methods: We searched the keywords in the online databases of Web of Science, Scopus, PubMed, and Cochrane on December 31, 2021. After duplicate removal, we performed the screening process in two stages; title/abstract and then full-text screening. The data of the eligible studies were extracted into a pre-designed word table. This study adhered to the PRISMA checklist and Newcastle−Ottawa Scale Bias Assessment tool. Results: Sixty-three publications were included in this review. Our study shows that among COVID-19 patients, particularly moderate to severe cases, the gut and lung microbiota was different compared to healthy individuals. In addition, the severity, and viral load of COVID-19 disease would probably also be influenced by the gut, and lung microbiota's composition. Conclusion: Our study concludes that there was a significant difference in the composition of the URT, and gut microbiota in COVID-19 patients compared to the general healthy individuals, with an increase in opportunistic pathogens. Further, research is needed to investigate the probable bidirectional association of COVID-19 and human microbiome. © 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC.
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