Tehran University of Medical Sciences

Science Communicator Platform

Share By
Necrotic, Apoptotic and Autophagic Cell Fates Triggered by Nanoparticles Publisher Pubmed



Mohammadinejad R1 ; Moosavi MA2 ; Tavakol S3 ; Vardar DO4 ; Hosseini A5 ; Rahmati M6 ; Dini L7 ; Hussain S8 ; Mandegary A9 ; Klionsky DJ10
Authors

Source: Autophagy Published:2019


Abstract

Nanomaterials have gained a rapid increase in use in a variety of applications that pertain to many aspects of human life. The majority of these innovations are centered on medical applications and a range of industrial and environmental uses ranging from electronics to environmental remediation. Despite the advantages of NPs, the knowledge of their toxicological behavior and their interactions with the cellular machinery that determines cell fate is extremely limited. This review is an attempt to summarize and increase our understanding of the mechanistic basis of nanomaterial interactions with the cellular machinery that governs cell fate and activity. We review the mechanisms of NP-induced necrosis, apoptosis and autophagy and potential implications of these pathways in nanomaterial-induced outcomes. Abbreviations: Ag, silver; CdTe, cadmium telluride; CNTs, carbon nanotubes; EC, endothelial cell; GFP, green fluorescent protein; GO, graphene oxide; GSH, glutathione; HUVECs, human umbilical vein endothelial cells; NP, nanoparticle; PEI, polyethylenimine; PVP, polyvinylpyrrolidone; QD, quantum dot; ROS, reactive oxygen species; SiO2, silicon dioxide; SPIONs, superparamagnetic iron oxide nanoparticles; SWCNT, single-walled carbon nanotubes; TiO2, titanium dioxide; USPION, ultra-small super paramagnetic iron oxide; ZnO, zinc oxide. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
1. Nano-Immunoengineering: Opportunities and Challenges, Current Opinion in Biomedical Engineering (2019)
2. Toxicity and Biocompatibility of Nanomaterials: In Vivo Studies, Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance (2022)
Experts (# of related papers)
Other Related Docs
12. Advancements Nanotechnology and Their Applications in Microbiology, Microbiology in the Era of Artificial Intelligence: Nanotechnology, Quantum, and Next Generation Sequencing (2025)
16. Mechanisms and Pathogenesis Underlying Environmental Chemical-Induced Necroptosis, Environmental Science and Pollution Research (2020)
17. Toxicology of Nanobiomaterials, Stem Cell Nanoengineering (2015)