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A Novel Bilayer Drug-Loaded Wound Dressing of Pvdf and Phb/Chitosan Nanofibers Applicable for Post-Surgical Ulcers Publisher



Amini F1 ; Semnani D1 ; Karbasi S2 ; Banitaba SN1
Authors
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Authors Affiliations
  1. 1. Department of textile engineering, Isfahan University of Technology, Isfahan, Iran
  2. 2. Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2019


Abstract

A novel bilayer nanofibrous wound dressing, with enhanced mechanical properties is successfully fabricated. This membrane, consisted of polyvinylidenefluoride (PVDF) nanofibers for providing tensile strength and polyhydroxybutyrate/chitosan (PHB/CTS) nanofibers loaded with gentamicin with ability of controlled drug delivery, is a great choice for post-surgical ulcers. Mechanical properties showed dramatically improvement of tensile strength by addition of PVDF layer. Gentamycin release represented both an immediate and a sustained release of about 24 h and 1 week, respectively and release increment with increase of CTS ratio. Results also revealed that drug release in structures follow first order kinetic and Fickian release mechanism. © 2018, © 2018 Taylor & Francis.
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