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Co-Expression of Cancer-Testis Antigens of Mage-A6 and Mage-A11 Is Associated With Tumor Aggressiveness in Patients With Bladder Cancer Publisher Pubmed



Mohsenzadegan M1 ; Razmi M2 ; Vafaei S3 ; Abolhasani M4, 5 ; Madjd Z2 ; Saeednejad Zanjani L2 ; Sharifi L6
Authors
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Authors Affiliations
  1. 1. Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Iran University of Medical Sciences (IUMS), Hemmat Highway, Tehran, Iran
  2. 2. Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Hemmat Street (Highway), Next To Milad Tower, Tehran, 1449614535, Iran
  3. 3. Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pathology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Hasheminejad Kidney Center, Iran University of Medical Sciences, (IUMS), Tehran, Iran
  6. 6. Uro‑Oncology Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Scientific Reports Published:2022


Abstract

Melanoma antigen gene (MAGE)-A6 and MAGE-A11 are two of the most cancer-testis antigens overexpressed in various types of cancers. However, the clinical and prognosis value of MAGE-A6 and MAGE-A11 co-expression in the pathophysiology of the bladder is unknown. Three studies were selected from GEO databases in order to introduce the common genes that are involved in bladder cancer. Then immunohistochemical analysis for staining pattern and clinicopathological significance of suggested markers, MAGE-A6 and MAGE-A11, were performed in 199 and 213 paraffin-embedded bladder cancer with long adjacent normal tissues, respectively. A significant and positive correlation was found between both nuclear and cytoplasmic expressions of MAGE-A6 as well as expression of cytoplasmic MAGE-A11 with histological grade, PT stage, lamina propria invasion, and LP/ muscularis (L/M) involvement (all of the p-values in terms of H-score were < 0.0001). Additionally, significant differences were found between both nuclear and cytoplasmic MAGE-A6/MAGE-A11 phenotypes with tumor size (P = 0.007, P = 0.043, respectively), different histological grades, PT stage, LP involvement, and L/M involvement (all of the p-values for both phenotypes were < 0.0001). The current study added the value of these novel markers to the bladder cancer clinical settlement that might be considered as an admirable target for immunotherapy. © 2022, The Author(s).
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