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Vaccine Design and Delivery Approaches for Covid-19 Publisher Pubmed



Shahzamani K1 ; Mahmoudian F2 ; Ahangarzadeh S3 ; Ranjbar MM4 ; Beikmohammadi L5, 6 ; Bahrami S7 ; Mohammadi E8, 9 ; Esfandyari S10 ; Alibakhshi A11 ; Javanmard SH8
Authors
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Authors Affiliations
  1. 1. Isfahan Gastroenterology and Hepatology Research Center (lGHRC), Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Razi Vaccine and Serum Research Institute, Agricultural Research, Education, Extension Organization (AREEO), Karaj, Iran
  5. 5. Department of Biochemistry, Erasmus University Medical Center, Rotterdam, Netherlands
  6. 6. Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, 14155-6559, Iran
  7. 7. Biotechnology Department, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
  8. 8. Applied Physiology Research Center, Cardiovascular Research Institute, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Core Research Facilities, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Source: International Immunopharmacology Published:2021


Abstract

COVID-19 is still a deadly disease that remains yet a major challenge for humans. In recent times, many large pharmaceutical and non-pharmaceutical companies have invested a lot of time and cost in fighting this disease. In this regard, today's scientific knowledge shows that designing and producing an effective vaccine is the best possible way to diminish the disease burden and dissemination or even eradicate the disease. Due to the urgent need, many vaccines are now available earlier than scheduled. New technologies have also helped to produce much more effective vaccines, although the potential side effects must be taken into account. Thus, in this review, the types of vaccines and vaccine designs made against COVID-19, the vaccination programs, as well as the delivery methods and molecules that have been used to deliver some vaccines that need a carrier will be described. © 2021 Elsevier B.V.
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