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Transcriptional Regulation of B Cell Class-Switch Recombination: The Role in Development of Noninfectious Complications Publisher Pubmed



Vlachiotis S1 ; Abolhassani H1, 2
Authors
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Authors Affiliations
  1. 1. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
  2. 2. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Expert Review of Clinical Immunology Published:2022


Abstract

Introduction: The process of immunoglobulin class switch recombination (CSR) occurs in secondary lymphoid organs. This highly regulated process is essential for the development of different antibody isotype maturation and long-life memory/plasma cell generation. Patients with impaired CSR present heterogeneous noninfectious complications. Areas covered: We provide an overview of recent advancements in the tight regulation of B cells before and during the CSR at different levels of cytokine stimulations, intracellular signaling, transcription-factor activation, gene transcription, and epigenetic controls. Expert opinion: Besides recurrent infections which result from the lack of production of class-switched immunoglobulins, intrinsic B cell signaling pathways and regulatory component defects have distinct roles in other immune-related clinical manifestations including autoimmunity, atopy, lymphoproliferation, and cancer. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
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