Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2-Aryl-Quinoline Derivatives As Aromatase Inhibitors and Anti-Breast Cancer Agents

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Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2-Aryl-Quinoline Derivatives As Aromatase Inhibitors and Anti-Breast Cancer Agents Publisher

Ghodsi R¹ ; Azizi E² ; Ferlin MG³ ; Pezzi V⁴ ; Zarghi A⁵

Source: Letters in Drug Design and Discovery Published:2016

Abstract

Some new quinoline derivatives were designed and synthesized to evaluate their biological activities as aromatase inhibitors and anti-breast cancer agents. Cytotoxicity of quinolines 8a-g against human breast cancer MCF-7 and T47D cell lines were evaluated. All the compounds 8a-g were more cytotoxic against MCF-7 cells in comparison with those of T47D which express aromatase mRNA less than MCF-7 cells. Their effects on Aromatase activity are also described. Our results showed that compound 8b inhibits aromatase enzyme activity more than reference drug Letrozol. © 2016 Bentham Science Publishers.

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Style	Citing Format
MLA	Ghodsi R, et al.. "Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2-Aryl-Quinoline Derivatives As Aromatase Inhibitors and Anti-Breast Cancer Agents." Letters in Drug Design and Discovery, vol. 13, no. 1, 2016, pp. 89-97.
APA	Ghodsi R, Azizi E, Ferlin MG, Pezzi V, Zarghi A (2016). Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2-Aryl-Quinoline Derivatives As Aromatase Inhibitors and Anti-Breast Cancer Agents. Letters in Drug Design and Discovery, 13(1), 89-97.
Chicago	Ghodsi R, Azizi E, Ferlin MG, Pezzi V, Zarghi A. "Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2-Aryl-Quinoline Derivatives As Aromatase Inhibitors and Anti-Breast Cancer Agents." Letters in Drug Design and Discovery 13, no. 1 (2016): 89-97.
Harvard	Ghodsi R et al. (2016) 'Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2-Aryl-Quinoline Derivatives As Aromatase Inhibitors and Anti-Breast Cancer Agents', Letters in Drug Design and Discovery, 13(1), pp. 89-97.
Vancouver	Ghodsi R, Azizi E, Ferlin MG, Pezzi V, Zarghi A. Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2-Aryl-Quinoline Derivatives As Aromatase Inhibitors and Anti-Breast Cancer Agents. Letters in Drug Design and Discovery. 2016;13(1):89-97.
BibTex	@article{ author = {Ghodsi R and Azizi E and Ferlin MG and Pezzi V and Zarghi A}, title = {Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2-Aryl-Quinoline Derivatives As Aromatase Inhibitors and Anti-Breast Cancer Agents}, journal = {Letters in Drug Design and Discovery}, volume = {13}, number = {1}, pages = {89-97}, year = {2016} }
RIS	TY - JOUR AU - Ghodsi R AU - Azizi E AU - Ferlin MG AU - Pezzi V AU - Zarghi A TI - Design, Synthesis and Biological Evaluation of 4-(Imidazolylmethyl)-2-Aryl-Quinoline Derivatives As Aromatase Inhibitors and Anti-Breast Cancer Agents JO - Letters in Drug Design and Discovery VL - 13 IS - 1 SP - 89 EP - 97 PY - 2016 ER -

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