Expression Study and Clinical Correlations of Myc and Ccat2 in Breast Cancer Patients

Expression Study and Clinical Correlations of Myc and Ccat2 in Breast Cancer Patients Publisher Pubmed

Sarrafzadeh S¹ ; Geranpayeh L² ; Tasharrofi B¹ ; Soudyab M¹ ; Nikpayam E¹ ; Iranpour M¹ ; Mirfakhraie R¹ ; Gharesouran J^{1, 3} ; Ghafourifard S⁴ ; Ghafourifard S⁴

Show Affiliations

1. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4. Department of Community and Preventive Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Biomedical Journal Published:2017

Abstract

Background: Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods: In the current study, we evaluated the expression of CCAT2 in breast cancer tissues with regards to the expression of its target MYC. In addition, we assessed the relationship between CCAT2 and MYC expression levels in tumor tissues and the clinical prognostic characteristics of breast cancer patients. Results: MYC expression levels were significantly up-regulated in tumor tissues compared with adjacent noncancerous tissues (ANCTs), while such analysis showed no statistically significant difference between these two tissue types in CCAT2 expression. Starkly increased CCAT2 gene expression levels were found in 12/48 (25%) of cancer tissue samples compared with their corresponding ANCTs. Furthermore, significant inverse correlations were found between CCAT2 expression and stage, as well as lymph node involvement. Besides, a significant inverse correlation was found between the relative MYC expression in tumor tissues compared with their corresponding ANCTs and disease stage. Conclusions: These results highlight the significance of MYC and CCAT2 expressions in the early stages of breast cancer development and suggest a potentially significant role for CCAT2 in a subset of breast cancer patients, which could be applied as a potential therapeutic target in these patients. © 2017, Pasteur Institute of Iran. All rights reserved.

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Style	Citing Format
MLA	Sarrafzadeh S, et al.. "Expression Study and Clinical Correlations of Myc and Ccat2 in Breast Cancer Patients." Iranian Biomedical Journal, vol. 21, no. 5, 2017, pp. 303-311.
APA	Sarrafzadeh S, Geranpayeh L, Tasharrofi B, Soudyab M, Nikpayam E, Iranpour M, Mirfakhraie R, Gharesouran J, Ghafourifard S, Ghafourifard S (2017). Expression Study and Clinical Correlations of Myc and Ccat2 in Breast Cancer Patients. Iranian Biomedical Journal, 21(5), 303-311.
Chicago	Sarrafzadeh S, Geranpayeh L, Tasharrofi B, Soudyab M, Nikpayam E, Iranpour M, Mirfakhraie R, Gharesouran J, Ghafourifard S, Ghafourifard S. "Expression Study and Clinical Correlations of Myc and Ccat2 in Breast Cancer Patients." Iranian Biomedical Journal 21, no. 5 (2017): 303-311.
Harvard	Sarrafzadeh S et al. (2017) 'Expression Study and Clinical Correlations of Myc and Ccat2 in Breast Cancer Patients', Iranian Biomedical Journal, 21(5), pp. 303-311.
Vancouver	Sarrafzadeh S, Geranpayeh L, Tasharrofi B, Soudyab M, Nikpayam E, Iranpour M, et al.. Expression Study and Clinical Correlations of Myc and Ccat2 in Breast Cancer Patients. Iranian Biomedical Journal. 2017;21(5):303-311.
BibTex	@article{ author = {Sarrafzadeh S and Geranpayeh L and Tasharrofi B and Soudyab M and Nikpayam E and Iranpour M and Mirfakhraie R and Gharesouran J and Ghafourifard S and Ghafourifard S}, title = {Expression Study and Clinical Correlations of Myc and Ccat2 in Breast Cancer Patients}, journal = {Iranian Biomedical Journal}, volume = {21}, number = {5}, pages = {303-311}, year = {2017} }
RIS	TY - JOUR AU - Sarrafzadeh S AU - Geranpayeh L AU - Tasharrofi B AU - Soudyab M AU - Nikpayam E AU - Iranpour M AU - Mirfakhraie R AU - Gharesouran J AU - Ghafourifard S AU - Ghafourifard S TI - Expression Study and Clinical Correlations of Myc and Ccat2 in Breast Cancer Patients JO - Iranian Biomedical Journal VL - 21 IS - 5 SP - 303 EP - 311 PY - 2017 ER -

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