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A Rapid Nanobiosensing Platform Based on Herceptin-Conjugated Graphene for Ultrasensitive Detection of Circulating Tumor Cells in Early Breast Cancer Publisher



Rahimzadeh Z1 ; Naghib SM1 ; Askari E2 ; Molaabasi F2 ; Sadr A3 ; Zare Y2 ; Afsharpad M4 ; Rhee KY5
Authors
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Authors Affiliations
  1. 1. Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology, P.O. Box 16846-13114, Tehran, Iran
  2. 2. Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  3. 3. Department of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran
  4. 4. Cancer Control Research Center, Cancer Control Foundation, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Mechanical Engineering (BK21 Four), College of Engineering, Kyung Hee University, Yongin, South Korea

Source: Nanotechnology Reviews Published:2021


Abstract

In this paper, we use a simple and cheap approach for the synthesis of herceptin-conjugated graphene biosensor to detect the HER2-positive breast cancer cells. The bifunctional graphene-herceptin nanosheets are prepared from graphite by a simple ultrasonic-mediated technique. The prepared protein-mediated graphene is fully characterized. The results show the exfoliation of graphene layers in herceptin solution. Moreover, herceptin is effectively conjugated into the surface of graphene nanosheets. The synthesized herceptin-conjugated graphene is applied for breast cancer detection. The linear range of this biosensor is 1-80 cells, which is significant. The biosensor shows an excellent selectivity performance for detection of HER2-positive cancer cells. Likewise, the stability and functionality of the biosensor is about 40 days. Based on the results, this device is a promising candidate for rapid and selective detection of cancer cells. © 2021 Zahra Rahimzadeh et al., published by De Gruyter 2021.
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