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Vaccine Breakthrough Hypoxemic Covid-19 Pneumonia in Patients With Auto-Abs Neutralizing Type I Ifns Publisher Pubmed



Bastard P1, 2, 3, 4 ; Vazquez SE5, 6, 7 ; Liu J8, 9 ; Laurie MT8 ; Wang CY10 ; Gervais A1, 2 ; Voyer TL1, 2 ; Bizien L1, 2 ; Zamecnik C11 ; Philippot Q1, 2 ; Rosain J1, 2 ; Catherinot E12 ; Willmore A10 ; Mitchell AM10 Show All Authors
Authors
  1. Bastard P1, 2, 3, 4
  2. Vazquez SE5, 6, 7
  3. Liu J8, 9
  4. Laurie MT8
  5. Wang CY10
  6. Gervais A1, 2
  7. Voyer TL1, 2
  8. Bizien L1, 2
  9. Zamecnik C11
  10. Philippot Q1, 2
  11. Rosain J1, 2
  12. Catherinot E12
  13. Willmore A10
  14. Mitchell AM10
  15. Bair R11
  16. Garcon P13
  17. Kenney H14
  18. Fekkar A1, 2, 15
  19. Salagianni M16
  20. Poulakou G17
  21. Siouti E16
  22. Sahanic S18
  23. Tancevski I18
  24. Weiss G18
  25. Nagl L19
  26. Manry J1, 2
  27. Duvlis S20, 21
  28. Arroyosanchez D22
  29. Artal EP22
  30. Rubio L8
  31. Perani C23
  32. Bezzi M24
  33. Sottini A25
  34. Quaresima V25
  35. Roussel L26, 27
  36. Vinh DC26, 27
  37. Reyes LF28, 29
  38. Garzaro M30
  39. Hatipoglu N31
  40. Boutboul D32
  41. Tandjaouilambiotte Y33, 34, 35
  42. Borghesi A36
  43. Aliberti A37
  44. Cassaniti I38
  45. Venet F39, 40, 41
  46. Monneret G39, 40
  47. Halwani R42, 43
  48. Sharifaskari NS42
  49. Danielson J14
  50. Burrel S44
  51. Morbieu C45
  52. Stepanovskyy Y46
  53. Bondarenko A46, 111
  54. Volokha A46
  55. Boyarchuk O47
  56. Gagro A48, 49
  57. Neuville M50
  58. Neven B51
  59. Keles S52
  60. Hernu R53
  61. Bal A54
  62. Novelli A55
  63. Novelli G56
  64. Saker K57, 58
  65. Ailioaie O59
  66. Antoli A60
  67. Jeziorski E61
  68. Rocamorablanch G60
  69. Teixeira C62
  70. Delaunay C63
  71. Lhuillier M64
  72. Turnier PL63
  73. Zhang Y14, 65
  74. Mahevas M66, 67, 68
  75. Panhammarstrom Q69, 143
  76. Abolhassani H69
  77. Bompoil T70
  78. Dorgham K71
  79. Gorochov G71, 72
  80. Laouenan C33, 73, 74
  81. Rodriguezgallego C75, 76
  82. Ng LFP77, 78
  83. Renia L77, 78, 79
  84. Pujol A80, 86, 180, 181
  85. Belot A57, 58, 82, 83, 107
  86. Raffi F63
  87. Allende LM22
  88. Martinezpicado J84, 85, 86, 87
  89. Ozcelik T88
  90. Imberti L25
  91. Notarangelo LD14, 170
  92. Troya J89
  93. Solanich X60
  94. Zhang SY1, 2, 3
  95. Puel A1, 2, 3
  96. Wilson MR11
  97. Trouilletassant S58, 90
  98. Abel L1, 2, 3
  99. Jouanguy E1, 2, 3
  100. Ye CJ10, 91, 92, 93, 94
  101. Cobat A1, 2, 3
  102. Thompson LM95
  103. Andreakos E16
  104. Zhang Q1, 2, 3
  105. Anderson MS7, 96
  106. Casanova JL1, 2, 3, 4, 216, 217
  107. Derisi JL8, 10
  108. Achille C36
  109. Aiuti A98
  110. Almuhsen S99
  111. Almulla F100
  112. Angelini M36
  113. Arias AA3, 101, 102
  114. Aytekin G103
  115. Baldanti F38, 104
  116. Banos A105
  117. Feldman HB106
  118. Bergami F38
  119. Biggs CM108
  120. Bogunovic D109
  121. Bolze A110
  122. Bousfiha AA112
  123. Brodin P113
  124. Bryceson Y114
  125. Bustamante CD115
  126. Butte MJ116
  127. Casari G117
  128. Christodoulou J118
  129. Clement B53
  130. Condinoneto A119
  131. Constantinescu SN120
  132. Conti F121
  133. Cooper MA122
  134. Daganou M123
  135. Dalgard CL124
  136. Desai M125
  137. Drolet BA126
  138. El Baghdadi J127
  139. Ergun R128
  140. Ergun D128
  141. Espinosapadilla S129
  142. Fellay J130, 131
  143. Flores C132, 133, 134, 135
  144. Franco JL136
  145. Froidure A137, 138
  146. Ghirardello S36
  147. Gregersen PK139
  148. Grimbacher B140
  149. Haerynck F141
  150. Hagin D142
  151. Hammarstrom L143
  152. Heath JR144
  153. Henrickson SE145, 146
  154. Hsieh EWY147
  155. Husebye E148
  156. Imai K149
  157. Itan Y150, 151
  158. Jarvis ED152
  159. Kanat F128
  160. Karamitros T153
  161. Kisand K154
  162. Kopcha V155
  163. Korda M155
  164. Ku CL156
  165. Lampropoulou V16
  166. Lau YL157
  167. Ling Y158
  168. Lucas CL159
  169. Maniatis T160
  170. Mansouri D161
  171. Marodi L162
  172. Meyts I163, 164, 165
  173. Milner JD166
  174. Mironska K167
  175. Mogensen TH168
  176. Mojoli F37
  177. Morandeira F60
  178. Morio T169
  179. Ofarrelly C171
  180. Okada S172
  181. Okamoto K173
  182. Pagani M37
  183. Papadaki M16
  184. Pape JW174
  185. De Diego RP175
  186. Perlin DS176
  187. Pesole G177
  188. Pession A121
  189. Piralla A38
  190. Pirounaki M105
  191. Planas AM178
  192. Prando C179
  193. Quintanamurci L182, 183
  194. Ramaswamy S184
  195. Rapti V17
  196. Resnick I185
  197. Rigobonnin R60
  198. Sanchoshimizu V186, 187
  199. Sediva A188
  200. Seppanen MRJ189, 190
  201. Shahrooei M191, 192
  202. Shcherbina A193
  203. Slaby O194
  204. Snow AL195
  205. Solerpalacin P196
  206. Spaan AN3, 197
  207. Syrigos K17
  208. Tangye SG198, 199
  209. Tayoun AA184
  210. Triantafyllia V16
  211. Tsiodras S200
  212. Tulek B128
  213. Turvey SE201
  214. Furkan Uddin KM202
  215. Uddin MJ203, 204
  216. Van De Beek D205
  217. Vatansev H206
  218. Von Bernuth H207, 208, 209
  219. Wauters J210
  220. Zatz M211
  221. Zawadzki P212
  222. Gok F213
  223. Emiroglu M214
  224. Alkan G215
  225. Yormaz B128
Show Affiliations
Authors Affiliations
  1. 1. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France
  2. 2. Imagine Institute, University of Paris Cite, Paris, France
  3. 3. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, United States
  4. 4. Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, Paris, France
  5. 5. Medical Scientist Training Program, University of California, San Francisco, San Francisco, 94143, CA, United States
  6. 6. Tetrad Graduate Program, University of California, San Francisco, San Francisco, 94143, CA, United States
  7. 7. Diabetes Center, University of California, San Francisco, San Francisco, 94143, CA, United States
  8. 8. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, 94158, CA, United States
  9. 9. University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, United States
  10. 10. Chan Zuckerberg Biohub, San Francisco, 94158, CA, United States
  11. 11. Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, United States
  12. 12. Pneumology Department, Foch Hospital, Suresne, France
  13. 13. Intensive Care Unit, Grand Hopital de l'Est Francilien Site de Marne-la-Vallee, Jossigny, France
  14. 14. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, United States
  15. 15. Service de Parasitologie-Mycologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France
  16. 16. Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
  17. 17. 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Sotiria General Hospital of Chest Diseases, Athens, Greece
  18. 18. Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria
  19. 19. Department of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria
  20. 20. Faculty of Medical Sciences, University Goce Delchev, Stip, North Macedonia
  21. 21. Institute of Public Health, Skopje, North Macedonia
  22. 22. Department of Immunology, Instituto de Investigacion Sanitaria Hospital 12 de Octubre (imas12), Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, CIBERINFEC, Madrid, Spain
  23. 23. Emergency Room, ASST Spedali Civili di Brescia, Brescia, Italy
  24. 24. Covid Unit, ASST Spedali Civili, Brescia, Italy
  25. 25. CREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy
  26. 26. Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montreal, QC, Canada
  27. 27. Infectious Disease Susceptibility Program, Research Institute-McGill University Health Centre, Montreal, QC, Canada
  28. 28. Department of Microbiology, Universidad de La Sabana, Chia, Colombia
  29. 29. Department of Critical Care Medicine, Clinica Universidad de La Sabana, Chia, Colombia
  30. 30. Department of Infectious Diseases, Necker Hospital for Sick Children, AP-HP, Paris, France
  31. 31. Pediatric Infectious Diseases Unit, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
  32. 32. Department of Immunology, Saint-Louis Hospital, AP-HP, Paris, France
  33. 33. INSERM UMR 1137 IAME, Paris, France
  34. 34. INSERM UMR 1272 Hypoxie and Poumon, Bobigny, France
  35. 35. Pneumology and Infectiology Department, CH Saint Denis, Saint-Denis, France
  36. 36. Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  37. 37. Anesthesia and Intensive Care, Rianimazione I, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  38. 38. Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  39. 39. Laboratoire d'Immunologie, Hospices Civils de Lyon, Hopital Edouard Herriot, Lyon, France
  40. 40. EA 7426, Pathophysiology of Injury-Induced Immunosuppression, Universite Claude Bernard Lyon 1, Hospices Civils de Lyon, Hopital Edouard Herriot-BioMerieux, Lyon, France
  41. 41. CIRI, INSERM U1111, CNRS, UMR5308, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1, Lyon, France
  42. 42. Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
  43. 43. Immunology Research Laboratory, College of Medicine, King Saud University, Riyadh, Saudi Arabia
  44. 44. Sorbonne Universite, INSERM U1136, Institut Pierre Louis d'Epidemiologie et de Sante Publique (iPLESP), AP-HP, Hopital Pitie Salpetriere, Service de Virologie, Paris, France
  45. 45. Internal Medicine Department, Louis Mourier Hospital, AP-HP, Paris, France
  46. 46. Shupyk National Healthcare, University of Ukraine, Kyiv, Ukraine
  47. 47. Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  48. 48. Department of Pediatrics, Children's Hospital Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
  49. 49. Josip Juraj Strossmayer University of Osijek, Medical Faculty Osijek, Osijek, Croatia
  50. 50. Intensive Care Unit, Foch Hospital, Suresnes, France
  51. 51. Department of Pediatrics Hematology Immunology and Rheumatology, Necker Hospital for Sick Children, AP-HP, Paris, France
  52. 52. Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
  53. 53. Service des Urgences, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France
  54. 54. Laboratoire de Virologie, Institut Agent Infectieux, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France
  55. 55. Laboratory of Medical Genetics, IRCCS Bambino Gesu Children's Hospital, Rome, Italy
  56. 56. Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy
  57. 57. Joint Research Unit, Hospices Civils de Lyon-bio Merieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Benite, France
  58. 58. International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France
  59. 59. Service de Genetique, Hopital Raymond Poincare, AP-HP, Garches, France
  60. 60. Department of Internal Medicine, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
  61. 61. General Pediatric Department, PCCEI, CeReMAIA, University of Montpellier, CHU Montpellier, Montpellier, France
  62. 62. Unidade de Infeciologia e Imunodeficiencias, Centro Materno-Infantil do Norte, Centro Hospitalar Universitario do Porto, Porto, Portugal
  63. 63. Department of Infectious Diseases, CHU Nantes, INSERM UIC 1413, CHU, Nantes, France
  64. 64. Geriatric Department, CHU Nantes, Hopital Bellier, Nantes, France
  65. 65. NIAID Clinical Genomics Program, NIH, Bethesda, MD, United States
  66. 66. Necker Enfants Malades Institute (INEM), INSERM U1151/CNRS UMR 8253, University of Paris Cite, Paris, France
  67. 67. Departement of Internal Medicine, Henri Mondor University Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), Paris-Est Creteil University (UPEC), Creteil, France
  68. 68. INSERM U955, Team 2, Mondor Biomedical Research Institute (IMRB), Paris-Est Creteil University (UPEC), Creteil, France
  69. 69. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, SE14183, Sweden
  70. 70. Biologie/Pathologie, CHU-Nantes-Hotel Dieu, Institut de Biologie, Nantes, France
  71. 71. Sorbonne Universite, Inserm, Centre d'Immunologie et des Maladies Infectieuses, (CIMI-Paris), Paris, France
  72. 72. Departement d'Immunologie, Assistance Publique Hopitaux de Paris (AP-HP), Hopital Pitie-Salpetriere, Paris, France
  73. 73. Universite de Paris, IAME UMR-S 1137, INSERM, Paris, France
  74. 74. Departement Epidemiologie Biostatistiques et Recherche Clinique, Hopital Bichat, AP-HP, Paris, France
  75. 75. Department of Clinical Sciences, University Fernando Pessoa Canarias, Canary Islands, Las Palmas de Gran Canaria, Spain
  76. 76. Department of Immunology, University Hospital of Gran Canaria Dr. Negrin, Canarian Health System, Las Palmas de Gran Canaria, Spain
  77. 77. A∗STAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore, Singapore
  78. 78. Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore, Singapore
  79. 79. School of Biological Sciences, Nanyang Technology University, Singapore, Singapore
  80. 80. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain
  81. 81. CNRS UMR 5308, ENS, UCBL, Lyon, France
  82. 82. National Referee Centre for Rheumatic, and Autoimmune and Systemic Diseases in Children (RAISE), Lyon, France
  83. 83. Immunopathology Federation LIFE, Hospices Civils de Lyon, Lyon, France
  84. 84. IrsiCaixa AIDS Research Institute, Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
  85. 85. Center for Health and Social Care Research (CESS), Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain
  86. 86. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain
  87. 87. CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain
  88. 88. Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
  89. 89. Department of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain
  90. 90. Hospices Civils de Lyon, Lyon, France
  91. 91. ImmunoX Initiative, University of California, San Francisco, San Francisco, 94143, CA, United States
  92. 92. Departments of Epidemiology and Biostatistics and Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, 94143, CA, United States
  93. 93. Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, 94143, CA, United States
  94. 94. Parker Institute for Cancer Immunotherapy, San Francisco, 94129, CA, United States
  95. 95. Departments of Psychiatry and Human Behavior and Neurobiology and Behavior, University of California, Irvine, Irvine, CA, United States
  96. 96. Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Francisco, San Francisco, 94143, CA, United States
  97. 97. Howard Hughes Medical Institute, New York, NY, United States
  98. 98. San Raffaele Telethon Institute for Gene Therapy, IRCCS Ospedale San Raffaele, Vita Salute San Raffaele University, Milan, Italy
  99. 99. Immunology Research Lab, Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
  100. 100. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Dasman, Kuwait
  101. 101. Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellin, Colombia
  102. 102. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia
  103. 103. Department of Immunology and Allergy, Konya City Hospital, Konya, Turkey
  104. 104. Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy
  105. 105. 2nd Department of Internal Medicine and Research Laboratory, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece
  106. 106. Genetics Institute, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  107. 107. HFME, Hospices Civils de Lyon, National Referee Centre RAISE, INSERM U1111, Universite de Lyon, Lyon, France
  108. 108. Department of Pediatrics, BC Children's and St. Paul's Hospitals, University of British Columbia, Vancouver, BC, Canada
  109. 109. Icahn School of Medicine at Mount Sinai, New York, NY, United States
  110. 110. Helix, San Mateo, CA, United States
  111. 111. Shupyk National Medical Academy for Postgraduate Education, Kyiv, Ukraine
  112. 112. Clinical Immunology Unit, Department of Pediatric Infectious Disease, CHU Ibn Rushd, Laboratoire d'Immunologie Clinique, Inflammation et Allergie (LICIA), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
  113. 113. SciLifeLab, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
  114. 114. Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden
  115. 115. Stanford University, Stanford, CA, United States
  116. 116. Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, The Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, United States
  117. 117. Clinical Genomics, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy
  118. 118. Murdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia
  119. 119. Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
  120. 120. de Duve Institute, Ludwig Cancer Research, Brussels, Belgium
  121. 121. Pediatric Unit, IRCCS Azienda Ospedaliero, Universitaria di Bologna, Bologna, Italy
  122. 122. Washington University School of Medicine, St. Louis, MO, United States
  123. 123. ICU, Sotiria General Hospital of Chest Diseases, Athens, Greece
  124. 124. Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
  125. 125. Bai Jerbai Wadia Hospital for Children, Mumbai, India
  126. 126. School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States
  127. 127. Genetics Unit, Military Hospital Mohamed V, Rabat, Morocco
  128. 128. Selcuk University, Department of Pulmonology, Konya, Turkey
  129. 129. Instituto Nacional de Pediatria (National Institute of Pediatrics), Mexico City, Mexico
  130. 130. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
  131. 131. Precision Medicine Unit, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
  132. 132. Research Unit, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
  133. 133. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
  134. 134. Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), Santa Cruz de Tenerife, Spain
  135. 135. Faculty of Health Sciences, University of Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain
  136. 136. Group of Primary Immunodeficiencies, University of Antioquia UDEA, Medellin, Colombia
  137. 137. Pulmonology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium
  138. 138. Institut de Recherche Experimentale et Clinique (IREC), Universite Catholique de Louvain, Brussels, Belgium
  139. 139. Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States
  140. 140. Center for Chronic Immunodeficiency, Institute for Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
  141. 141. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Laboratory, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
  142. 142. Genetics Institute Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
  143. 143. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
  144. 144. Institute for Systems Biology, Seattle, WA, United States
  145. 145. Department of Pediatrics, Division of Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, United States
  146. 146. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
  147. 147. Departments of Pediatrics, Immunology and Microbiology, University of Colorado, School of Medicine, Aurora, CO, United States
  148. 148. Department of Medicine, Haukeland University Hospital, Bergen, Norway
  149. 149. Department of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
  150. 150. Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  151. 151. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  152. 152. Laboratory of Neurogenetics of Language, Howard Hughes Medical Institute, Rockefeller University, New York, NY, United States
  153. 153. Bioinformatics and Applied Genomics Unit, Hellenic Pasteur Institute, Athens, Greece
  154. 154. Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
  155. 155. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  156. 156. Chang Gung University, Taoyuan County, Taiwan
  157. 157. Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, Hong Kong
  158. 158. Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
  159. 159. Department of Immunobiology, Yale University School of Medicine, New Haven, CT, United States
  160. 160. Zukerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States
  161. 161. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran
  162. 162. Primary Immunodeficiency Clinical Unit and Laboratory, Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
  163. 163. Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium
  164. 164. KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium
  165. 165. Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium
  166. 166. Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, United States
  167. 167. University Clinic for Children's Diseases, Department of Pediatric Immunology, Medical Faculty, University St. Cyril and Methodij, Skopje, North Macedonia
  168. 168. Department of Biomedicine, Aarhus University, Aarhus, Denmark
  169. 169. Tokyo Medical and Dental University Hospital, Tokyo, Japan
  170. 170. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
  171. 171. Comparative Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland
  172. 172. Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  173. 173. Tokyo Medical and Dental University, Tokyo, Japan
  174. 174. Haitian Study Group for Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti
  175. 175. Institute of Biomedical Research of IdiPAZ, University Hospital La Paz, Madrid, Spain
  176. 176. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, United States
  177. 177. Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari A. Moro, Bari, Italy
  178. 178. IIBB-CSIC, IDIBAPS, Barcelona, Spain
  179. 179. Faculdades Pequeno Principe, Instituto de Pesquisa Pele Pequeno Principe, Curitiba, Brazil
  180. 180. Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
  181. 181. Center for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Barcelona, Spain
  182. 182. Human Evolutionary Genetics Unit, CNRS U2000, Institut Pasteur, Paris, France
  183. 183. College de France, Paris, France
  184. 184. Al Jalila Children's Hospital, Dubai, United Arab Emirates
  185. 185. University Hospital St. Marina, Varna, Bulgaria
  186. 186. Department of Paediatric Infectious Diseases and Virology, Imperial College London, London, United Kingdom
  187. 187. Centre for Paediatrics and Child Health, Faculty of Medicine, Imperial College London, London, United Kingdom
  188. 188. Department of Immunology, Second Faculty of Medicine, Charles University, V Uvalu, University Hospital in Motol, Prague, Czech Republic
  189. 189. Adult Immunodeficiency Unit, Inflammation Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland
  190. 190. Rare Diseases Center, Pediatric Research Center, Children's Hospital, University of Helsinki, Helsinki University Hospital, Helsinki, Finland
  191. 191. Specialized Immunology Laboratory of Dr. Shahrooei, Ahvaz, Iran
  192. 192. Department of Microbiology and Immunology, Clinical and Diagnostic Immunology, KU Leuven, Leuven, Belgium
  193. 193. Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation
  194. 194. Central European Institute of Technology, Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
  195. 195. Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
  196. 196. Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron Barcelona Hospital Campus, Catalonia, Barcelona, Spain
  197. 197. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands
  198. 198. Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
  199. 199. St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Kensington, NSW, Australia
  200. 200. 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Attikon University General Hospital, Athens, Greece
  201. 201. BC Children's Hospital, University of British Columbia, Vancouver, Canada
  202. 202. Centre for Precision Therapeutics, Genetics and Genomic Medicine Centre, NeuroGen Children's Healthcare and Lecturer, Holy Family Red Crescent Medical College, Dhaka, Bangladesh
  203. 203. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates
  204. 204. Cellular Intelligence (Ci) Lab, GenomeArc Inc., Toronto, ON, Canada
  205. 205. Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
  206. 206. Necmettin Erbakan University, Department of Pulmonology, Konya, Turkey
  207. 207. Department of Pediatric Pneumology, Immunology and Intensive Care, Charite Universitatsmedizin, Berlin University Hospital Center, Berlin, Germany
  208. 208. Labor Berlin GmbH, Department of Immunology, Berlin, Germany
  209. 209. Berlin Institutes of Health (BIH), Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany
  210. 210. Department of General Internal Medicine, Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
  211. 211. Biosciences Institute, University of Sao Paulo, Sao Paulo, Brazil
  212. 212. Molecular Biophysics Division, Faculty of Physics, A. Mickiewicz University, Poznan, Poland
  213. 213. Necmettin Erbakan University, Division of Intensive Care Unit, Konya, Turkey
  214. 214. Selcuk University, Division of Pediatric Infectious Disease, Konya, Turkey
  215. 215. Division of Pediatric Infectious Disease, Konya, Turkey
  216. 216. Rockefeller University, Howard Hughes Medical Institute, New York, NY, United States
  217. 217. Necker Hospital for Sick Children, INSERM, Paris, France

Source: Science Immunology Published:2023


Abstract

Life-threatening breakthroughcases of critical COVID-19 are attributed to poor or waning antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; their contribution to hypoxemic breakthrough cases in vaccinated people is unknown. We studied a cohort of 48 individuals (aged 20 to 86 years) who received two doses of a messenger RNA (mRNA) vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Ab levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal Ab response to the vaccine. Among them, 10 (24%) had auto-Abs neutralizing type I IFNs (aged 43 to 86 years). Eight of these 10 patients had auto-Abs neutralizing both IFN-a2 and IFN-w, whereas two neutralized IFN-w only. No patient neutralized IFN-b. Seven neutralized type I IFNs at 10 ng/ml and three at 100 pg/ml only. Seven patients neutralized SARS-CoV-2 D614G and Delta efficiently, whereas one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only type I IFNs at 100 pg/ml neutralized both D614G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating Abs capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a notable proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population. Copyright © 2023 The Authors, some rights reserved.
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