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Investigation of Iron Oxide Nanoparticle Cytotoxicity in Relation to Kidney Cells: A Mathematical Modeling of Data Mining Publisher Pubmed



Hataminia F1, 2 ; Noroozi Z3 ; Mobaleghol Eslam H1
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, Iran
  2. 2. Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Toxicology in Vitro Published:2019


Abstract

Iron oxide nanoparticles (IONs) have several applications in medical fields including magnetic resonance imaging (MRI), drug delivery, cancer treatment and cell splitting. Therefore, it is important to investigate their cellular toxicity. It is difficult to predict their cellular toxicity due to complexities associated with their cellular mechanisms. The present study was designed to collect data on the cell viability of IONs and obtain a mathematical modeling. For this purpose, particle size, concentration, incubation time and the surface charge of NPs were selected as the model inputs and the percentage of cell viability (%CV) as the model output. Using a version of the modeling called SA-LOOCV-GRBF, these issues can be resolved with favorable results. Since the behavior of positive zeta potential (PZP) is different from negative zeta potential (NZP), they were compared by separate modeling efforts. Kidney is a vital body organ that dispose of IONs in the body, but it is possible that these cells engage in unwanted interactions with IONs. Therefore, the kidney cell line was examined in this study. © 2019
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