Urine Exosome Gene Expression of Cancer-Testis Antigens for Prediction of Bladder Carcinoma

Urine Exosome Gene Expression of Cancer-Testis Antigens for Prediction of Bladder Carcinoma Publisher

Yazarlou F¹ ; Mowla SJ² ; Oskooei VK³ ; Motevaseli E⁴ ; Tooli LF⁵ ; Afsharpad M⁶ ; Nekoohesh L⁷ ; Sanikhani NS⁴ ; Ghafourifard S³ ; Modarressi MH¹

Show Affiliations

1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Faculty of Biological Sciences, Department of Genetics, Tarbiat Modares University, Tehran, Iran
3. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Microbiology, School of Biology, College of Science, Tehran University, Tehran, Iran
6. Cancer Control Research Center, Cancer Control Foundation, Iran University of Medical Sciences, Tehran, Iran
7. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Cancer Management and Research Published:2018

Abstract

Background: Exosomes have been regarded as emerging tools for cancer diagnosis. Tumor-derived exosomes contain molecules that enhance cancer progression and affect immune responses. Material and methods: In the present study, we evaluated expression of seven cancer-testis antigens (CTAs) that are regarded as putative biomarkers and immunotherapeutic targets along with NMP22 in urinary exosomes of bladder cancer patients, healthy subjects and patients affected with nonmalignant urinary disorders. Results: Exosomal expression of MAGE-B4 was significantly higher in bladder cancer patients compared with normal samples (expression ratio=2.68, P=0.01). However, its expression was lower in bladder cancer patients compared with benign prostate hyperplasia (BPH) patients (expression ratio=0.17, P=0.01). Exosomal expression of NMP22 was significantly higher in bladder cancer patients compared with BPH patients (expression ratio=9.22, P=0.02). Expressions of other genes were not significantly different between bladder cancer patients and normal/ nonmalignant samples. We found significant correlation between MAGE-A3 and MAGE-B4 expressions in exosomes obtained from controls. In addition, TSGA10 expression was correlated with expression of NMP22 in both cancer patients and controls. Conclusion: The present study provides evidences for differential expression of CTAs in urinary exosomes of bladder cancer patients and urogenital disorders and warrants further studies for assessment of their significance in cancer diagnosis and immunotherapeutic approaches. © 2018 Yazarlou et al.

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Mohammad Hossein Modarressi (3)

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Style	Citing Format
MLA	Yazarlou F, et al.. "Urine Exosome Gene Expression of Cancer-Testis Antigens for Prediction of Bladder Carcinoma." Cancer Management and Research, vol. 10, no. , 2018, pp. 5373-5381.
APA	Yazarlou F, Mowla SJ, Oskooei VK, Motevaseli E, Tooli LF, Afsharpad M, Nekoohesh L, Sanikhani NS, Ghafourifard S, Modarressi MH (2018). Urine Exosome Gene Expression of Cancer-Testis Antigens for Prediction of Bladder Carcinoma. Cancer Management and Research, 10(), 5373-5381.
Chicago	Yazarlou F, Mowla SJ, Oskooei VK, Motevaseli E, Tooli LF, Afsharpad M, Nekoohesh L, Sanikhani NS, Ghafourifard S, Modarressi MH. "Urine Exosome Gene Expression of Cancer-Testis Antigens for Prediction of Bladder Carcinoma." Cancer Management and Research 10, no. (2018): 5373-5381.
Harvard	Yazarlou F et al. (2018) 'Urine Exosome Gene Expression of Cancer-Testis Antigens for Prediction of Bladder Carcinoma', Cancer Management and Research, 10(), pp. 5373-5381.
Vancouver	Yazarlou F, Mowla SJ, Oskooei VK, Motevaseli E, Tooli LF, Afsharpad M, et al.. Urine Exosome Gene Expression of Cancer-Testis Antigens for Prediction of Bladder Carcinoma. Cancer Management and Research. 2018;10():5373-5381.
BibTex	@article{ author = {Yazarlou F and Mowla SJ and Oskooei VK and Motevaseli E and Tooli LF and Afsharpad M and Nekoohesh L and Sanikhani NS and Ghafourifard S and Modarressi MH}, title = {Urine Exosome Gene Expression of Cancer-Testis Antigens for Prediction of Bladder Carcinoma}, journal = {Cancer Management and Research}, volume = {10}, number = {}, pages = {5373-5381}, year = {2018} }
RIS	TY - JOUR AU - Yazarlou F AU - Mowla SJ AU - Oskooei VK AU - Motevaseli E AU - Tooli LF AU - Afsharpad M AU - Nekoohesh L AU - Sanikhani NS AU - Ghafourifard S AU - Modarressi MH TI - Urine Exosome Gene Expression of Cancer-Testis Antigens for Prediction of Bladder Carcinoma JO - Cancer Management and Research VL - 10 IS - SP - 5373 EP - 5381 PY - 2018 ER -

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