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Effect of Turmeric on Glycemic Status, Lipid Profile, Hs-Crp, and Total Antioxidant Capacity in Hyperlipidemic Type 2 Diabetes Mellitus Patients Publisher Pubmed



Adab Z1 ; Eghtesadi S2 ; Vafa MR2 ; Heydari I3 ; Shojaii A4 ; Haqqani H5 ; Arablou T6 ; Eghtesadi M7
Authors
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Authors Affiliations
  1. 1. Nutrition, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Nutrition, Faculty of Public Health, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Internal Medicine, Institute of Endocrinology and Metabolism, Endocrine Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Research, Institute for Islamic and Complementary Medicine and School of Traditional Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biostatistics, Faculty of Public Health, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Nutrition, Department of Nutrition, Faculty of Public Health, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Tehran Medical Branch, School of Medicine, Azad University, Tehran, Iran

Source: Phytotherapy Research Published:2019


Abstract

Diabetes mellitus is the most common metabolic disorder worldwide. This study examined the effect of turmeric supplementation on glycemic status, lipid profile, hs-CRP and total antioxidant capacity in hyperlipidemic type 2 diabetic patients. In this double-blind, randomized clinical trial, 80 hyperlipidemic type 2 diabetic patients were divided into turmeric (2,100 mg powdered rhizome of turmeric daily) and placebo groups for 8 weeks. Body weight, fasting plasma glucose, hemoglobin A1c (HbA1c), serum insulin, triglyceride (TG), total cholesterol, low density lypoprotein cholesterol (LDL-c), high density lypoprotein cholesterol, apolipoprotein A1, apolipoprotein B, high sensitivity C-reactive protein (hs-CRP), and total antioxidant capacity were measured before and after intervention. Statistical analysis was carried out using paired and independent t and chi-square tests. Seventy five patients completed the study. The turmeric group showed significant decreases in body weight, TG, and LDL-c compared with baseline (p value < 0.05). Body mass index, TG, and total cholesterol decreased significantly in the turmeric group compared with the placebo group (p value < 0.05). No significant changes were observed in other parameters between the two groups after intervention (p value < 0.05). Turmeric improved some fractions of lipid profile and decreased body weight in hyperlipidemic patients with type 2 diabetes. It had no significant effect on glycemic status, hs-CRP, and total antioxidant capacity in these patients. © 2019 John Wiley & Sons, Ltd.
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