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Recent Progress in the Graphene-Based Biosensing Approaches for the Detection of Alzheimer's Biomarkers Publisher Pubmed



Rouhi N1 ; Akhgari A2, 3 ; Orouji N4 ; Nezami A5 ; Rahimzadegan M6 ; Kamali H2, 3
Authors
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Authors Affiliations
  1. 1. Seafood Processing Department, Marine Science Faculty, Tarbiat Modares University, Tehran, Iran
  2. 2. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Food and Drug Administration, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Pharmaceutical and Biomedical Analysis Published:2023


Abstract

Alzheimer's disease (AD) is one of the most common types of neurodegenerative disorders. It is possible to identify AD early thanks to the measurement of specific biomarker levels. Owing to crucial roles of biomarkers in the AD, the detection of AD-related biomarkers may be suitable for predictive identification of AD. Biosensors is a novel tool that could be beneficial to appreciate recognition of several AD biomarkers as early as possible. Graphene and its derivatives containing graphene oxide (GO) and reduced-GO (rGO) can be good choice for biosensing approaches due to their unique properties. GO/rGO-based biosensors or nanosensors have been widely used for the determination of AD biomarkers. In this article, the general aspects of AD, its biomarkers, biosensors, and GO are overviewed. In addition, this review provides the current developments in the applications of graphene-based biosensors for recognition of AD biomarkers. Future perspectives and challenges of graphene-based biosensing as a new approach for detection of AD are discussed in brief as well. © 2022 Elsevier B.V.
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