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Short-Term Comparison of Accelerated and Standard Methods of Corneal Collagen Crosslinking Publisher Pubmed



Hashemi H1 ; Fotouhi A2 ; Miraftab M1 ; Bahrmandy H1 ; Seyedian MA1 ; Amanzadeh K1 ; Heidarian S1 ; Nikbin H1 ; Asgari S3
Authors
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Authors Affiliations
  1. 1. Noor Ophthalmology Research Center, Noor Eye Hospital, Number 96 Esfandiar Boulevard, Vali'asr Avenue, Tehran, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cataract and Refractive Surgery Published:2015


Abstract

Purpose To compare the 6-month results of accelerated and standard collagen crosslinking (CXL) treatment of progressive keratoconus. Setting Noor Eye Hospital, Tehran, Iran. Design Prospective randomized clinical trial. Methods Two groups of eyes (intervention and control) received corneal collagen crosslinking (CXL) treatment. The intervention group received accelerated CXL (18 mW/cm2, 5 minutes), and the control group received standard CXL (3 mW/cm2, 30 minutes). The eyes were evaluated for changes in the visual indices, refraction, and topography preoperatively and 1, 3, and 6 months postoperatively and regarding corneal rigidity indices and the endothelial cell count (ECC) preoperatively and at 6 months. Results The study evaluated 62 eyes (31 patient) in 2 groups. The mean changes in uncorrected (P =.733) and corrected (P =.646) distance visual acuities and manifest refraction spherical equivalent (P =.598) did not differ statistically significantly between the 2 groups. The central corneal thickness was higher in the standard group than the accelerated group (P =.025). The mean decrease in the maximum keratometry (K) (P =.865) and mean K (P =.974) and the mean changes in the asphericity (P =.272) were not statistically significantly different between the 2 groups. The mean changes in corneal hysteresis (CH) (P =.548) and the corneal resistance factor (CRF) (P = 1.000), CH-CRF (P =.282), and the area under the peak 2 (P =.260) were similar in both groups. The mean decrease in the ECC was not statistically significantly different between the 2 groups (P =.218). Conclusion Based on 6-month results, accelerated and standard corneal CXL arrested the progression of keratoconus similarly. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned. © 2015 ASCRS and ESCRS.
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