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Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development Publisher



Moosavi MA1 ; Rahmati M2 ; Ashtari N3 ; Alizadeh J3 ; Hashemi M4 ; Bathaei SZ5 ; Ghavami S3, 6
Authors
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Authors Affiliations
  1. 1. Department of Molecular Medicine, Institute of Medical Biotechnology, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran
  2. 2. Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Human Anatomy and Cell Science, Rady College of Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
  4. 4. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  5. 5. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Health Policy Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Contemporary Clinical Neuroscience Published:2017


Abstract

Development is an evolutionary process that is tightly regulated in mammalian species. Several different cascades are involved in different stages of development. Among these mechanisms, apoptosis, autophagy, and unfolded protein response play critical roles in regulation of development by affecting the cell fate. All of these pathways are involved in regulation of cell number via determining the life and death cycles of the cells. In this chapter, we first explain the brief mechanisms that are involved in regulation of apoptosis, autophagy, and unfolded protein response, and later, we briefly describe how these mechanisms play roles in general development. We then discuss the importance of these pathways in regulation of cerebellar development. © 2017, Springer International Publishing AG.
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