Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Microrna-Binding Site Polymorphisms and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Gholami M1, 2 ; Larijani B2 ; Sharifi F3 ; Hasaniranjbar S1 ; Taslimi R4 ; Bastami M5 ; Atlasi R6 ; Amoli MM7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Gastroenterology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Evidence Based Practice Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Cancer Medicine Published:2019


Abstract

Genetic variations in miRNAs binding site might participate in cancer risk. This study aimed to systematically review the association between miRNA-binding site polymorphisms and colorectal cancer (CRC). Electronic literature search was carried out on PubMed, Web of Science (WOS), Scopus, and Embase. All types of observational studies till 30 November 2018 were included. Overall 85 studies (21 SNPs) from two systematic searches were included analysis. The results showed that in the Middle East population, the minor allele of rs731236 was associated with decreased risk of CRC (heterozygote model: 0.76 [0.61-0.95]). The minor allele of rs3025039 was related to increased risk of CRC in East Asian population (allelic model: 1.25 [1.01-1.54]). Results for rs3212986 were significant in overall and subgroup analysis (P <.05). For rs1801157 in subgroup analysis the association was significant in Asian populations (including allelic model: 2.28 [1.11-4.69]). For rs712, subgroup analysis revealed a significant (allelic model: 1.41 [1.23-1.61]) and borderline (allelic model: 0.92 [0.84-1.00]) association in Chinese and Czech populations, respectively. The minor allele of rs17281995 increased risk of CRC in different genetic models (P <.05). Finally, rs5275, rs4648298, and rs61764370 did not show significant associations. In conclusion, minor allele of rs3025039, rs3212986, and rs712 polymorphisms increases the risk of CRC in the East Asian population, and heterozygote model of rs731236 polymorphism shows protective effect in the Middle East population. In Europeans, the minor allele of rs17281995 may increase the risk of CRC, while rs712 may have a protective effect. Further analysis based on population stratifications should be considered in future studies. © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Association of Mirna Targetome Variants in Lamc1 and Gnb3 Genes With Colorectal Cancer and Obesity, Cancer Medicine (2022)
2. Microrna-Related Single-Nucleotide Polymorphisms and Breast Cancer, Journal of Cellular Physiology (2021)
3. Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review, Frontiers in Oncology (2022)
4. Micrornas As Biomarkers for Early Diagnosis, Targeting and Prognosis of Prostate Cancer, Pathology Research and Practice (2023)
5. International Epidemiology of Liver Cancer: Geographical Distribution, Secular Trends and Predicting the Future, Journal of Preventive Medicine and Hygiene (2020)
6. Association of Microrna Gene Polymorphisms With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis, Journal of Research in Medical Sciences (2020)
7. Bioinformatics Prioritization of Snps Perturbing Microrna Regulation of Hematological Malignancy-Implicated Genes, Genomics (2015)
8. The Role of Inflammatory Mirna–Mrna Interactions in Pbmcs of Colorectal Cancer and Obesity Patients, Immunity# Inflammation and Disease (2022)
Experts (# of related papers)
View all Related Experts
Bagher Larijani (6)
Mahsa Mohamad Amoli (6)
Other Related Docs
9. Association and in Silico Investigations of Mir-302C Insertion/Deletion Variant As a Novel Biomarker With Susceptibility to Gastric Cancer, Journal of Cellular Biochemistry (2019)
10. Preterm Birth and Breast Cancer Risk: A Systematic Review and Meta-Analysis, Asian Pacific Journal of Cancer Prevention (2023)
11. An in Silico Approach to Identify and Prioritize Mirnas Target Sites Polymorphisms in Colorectal Cancer and Obesity, Cancer Medicine (2020)
12. Upregulated Mir-410 Is Linked to Poor Prognosis in Colorectal Cancer, British Journal of Biomedical Science (2020)
13. Systematic Review and Meta-Analysis of the Association Between the Use of Sglt2 Inhibitors and Hepatocellular Carcinoma, Immunopathologia Persa (2025)
14. Hif-1Α Gene/Protein and Oxidative Stress in Patients With Colorectal Cancer: A Pilot Study, Gene Reports (2023)
15. Integrative Analyses of Triple Negative Dysregulated Transcripts Compared With Non-Triple Negative Tumors and Their Functional and Molecular Interactions, Journal of Cellular Physiology (2019)
16. A Systematic Review and Meta-Analysis to Evaluate Blood Levels of Interleukin-6 in Lung Cancer Patients, Kardiochirurgia i Torakochirurgia Polska (2023)
17. Demineralized Bone Matrix in Anterior Cervical Discectomy and Fusion: A Systematic Review, European Spine Journal (2017)
18. The Survival Rate of Hepatocellular Carcinoma in Asian Countries: A Systematic Review and Meta-Analysis, EXCLI Journal (2020)
19. Autophagy and Gastrointestinal Cancers: The Behind the Scenes Role of Long Non-Coding Rnas in Initiation, Progression, and Treatment Resistance, Cancer Gene Therapy (2021)
20. Ptgs2 Over-Expression: A Colorectal Carcinoma Initiator Not an Invasive Factor, Reports of Biochemistry and Molecular Biology (2021)
21. Comparison of Organs at Risk Doses Between Deep Inspiration Breath-Hold and Free-Breathing Techniques During Radiotherapy of Left-Sided Breast Cancer: A Meta-Analysis, Polish Journal of Medical Physics and Engineering (2022)
22. Ets Transcription Factor Elk3 in Human Cancers: An Emerging Therapeutic Target, Pathology Research and Practice (2023)
23. Oncoplastic Repair in Breast Conservation: Comprehensive Evaluation of Techniques and Oncologic Outcomes of 937 Patients, Clinical Breast Cancer (2020)
24. Mir196a2 Rs11614913 Contributes to Susceptibility to Colorectal Cancer in Iranian Population: A Multi-Center Case-Control Study and Meta-Analysis, Gene (2018)
25. Association Between Calcium Intake and Risk of Breast Cancer: An Updated Systematic Review and Dose–Response Meta-Analysis of Cohort Studies, Clinical Nutrition ESPEN (2023)
26. Mirnas: Emerging Agents for Therapeutic Effects of Polyphenols on Ovarian Cancer, Mini-Reviews in Medicinal Chemistry (2024)
27. The Effect of Metformin on Biomarkers Associated With Breast Cancer Outcomes: A Systematic Review, Meta-Analysis, and Dose–Response of Randomized Clinical Trials, Clinical and Translational Oncology (2020)
28. Lncrnas Roles in Chemoresistance of Cancer Cells, Current Molecular Medicine (2022)
29. Cancer Immunotherapy Confers a Global Benefit, Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors (2020)
30. Diagnosis of Cervical Cancer and Pre-Cancerous Lesions by Artificial Intelligence: A Systematic Review, Diagnostics (2022)
31. Liquid Biopsy in Female Genital Tract (Ovarian Cancer, Endometrial Tumor, and Cervical Tumor), Liquid Biopsy in Urogenital Cancers and its Clinical Utility (2022)
32. Global Research Trends on Colorectal Cancer (2014-2023): A Scientometric and Visualized Study, Archives of Iranian Medicine (2024)
33. An Exon Variant in Insulin Receptor Gene Is Associated With Susceptibility to Colorectal Cancer in Women, Tumor Biology (2015)
34. Association of Interleukin-6 Polymorphisms With Obesity: A Systematic Review and Meta-Analysis, Cytokine (2019)
35. In Silico Dissection of Mirna Targetome Polymorphisms and Their Role in Regulating Mirna-Mediated Gene Expression in Esophageal Cancer, Cell Biochemistry and Biophysics (2016)
36. A New World of Biomarkers and Therapeutics for Female Reproductive System and Breast Cancers: Circular Rnas, Frontiers in Cell and Developmental Biology (2020)
37. Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis, Asian Pacific Journal of Cancer Prevention (2019)
38. Corticosteroid Administration to Prevent Complications of Anterior Cervical Spine Fusion: A Systematic Review, Global Spine Journal (2018)
39. Prediction of Local Recurrence After Oncoplastic Breast Surgery: Analysis of a Large Cohort, Journal of Surgical Research (2021)
40. Curcumin and Its Novel Formulations for the Treatment of Hepatocellular Carcinoma: New Trends and Future Perspectives in Cancer Therapy, Journal of Functional Foods (2023)
41. Prediction of Anti-Cd25 and 5-Fu Treatments Efficacy for Pancreatic Cancer Using a Mathematical Model, BMC Cancer (2021)
42. Vitamin D Role in Hepatitis B: Focus on Immune System and Genetics Mechanism, Heliyon (2022)
43. Long Non-Coding Rna As a Potential Diagnostic Biomarker in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis, PLoS ONE (2023)
44. The Role of Lymph Node Ratio in Predicting Survival in Patients With Esophageal Squamous Cell Carcinoma, Journal of Iranian Medical Council (2022)
45. Cancer Incidence in Iran in 2014: Results of the Iranian National Population-Based Cancer Registry, Cancer Epidemiology (2019)
46. Cox-2 in Radiotherapy: A Potential Target for Radioprotection and Radiosensitization, Current Molecular Pharmacology (2018)
47. Association Between Il-8 (-251T/A) and Il-6 (-174G/C) Polymorphisms and Oral Cancer Susceptibility: A Systematic Review and Meta-Analysis, Medicina (Lithuania) (2021)
48. Coumarins and Gastrointestinal Cancer: A New Therapeutic Option?, Frontiers in Oncology (2021)
49. Prognostic Value of Microrna-125A/B Family in Patients With Gastric Cancer: A Meta-Analysis, Gastroenterology and Hepatology from Bed to Bench (2021)
50. Association of Dna Repair Gene Variants With Colorectal Cancer: Risk, Toxicity, and Survival, BMC Cancer (2020)