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Immune Cell Vaccine For Cancer Publisher



Razi S1, 2 ; Rezaei N3, 4, 5
Authors
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Authors Affiliations
  1. 1. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  2. 2. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives Published:2019


Abstract

Cancer vaccines have been studied for several years. The focus of these vaccines is treatment of patients with cancer. One of the several types of these vaccines is immune cell vaccine. Dendritic cells (DCs), which are a type of antigen presenting cells, have been widely used for development of immune cell vaccines. These cells can be loaded with different tumor-associated antigens (TAAs), including whole tumor cell lysates, RNA, peptides, and tumor cells. Patients receive these DC-based vaccines, then the DCs present TAAs to immune system and activate antigen-specific immune responses against the tumor. This chapter will briefly explain the DC-based tumor vaccines, their clinical trials, advantages and disadvantages, and then will discuss several methods that can help to optimize these vaccines. © 2019 Nima Rezaei and Mahsa Keshavarz-Fathi Published by Elsevier Ltd. All rights reserved.
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