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The Effects of Ca1 5Ht4 Receptors in Mk801-Induced Amnesia and Hyperlocomotion Publisher Pubmed



Nasehi M1 ; Tabatabaie M2 ; Khakpai F2 ; Zarrindast MR1, 2, 3, 4
Authors
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Authors Affiliations
  1. 1. Medical Genomics Research Center and School of Advanced Sciences in Medicine, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran
  2. 2. Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  3. 3. Department of Pharmacology and Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran

Source: Neuroscience Letters Published:2015


Abstract

In this study, the effects of 5-HT4 receptors of the CA1 on MK801-induced amnesia and hyperlocomotion were examined. One-trial step-down method was used to assess memory retention and then, the hole-board method to assess exploratory behaviors. The results showed that post-training intra-CA1 administration of RS67333 (62.5 and 625. ng/mouse) and RS23597 (1 and 10. ng/mouse) decreased memory consolidation, but it did not alter head-dip counts, head-dip latency and locomotor activity. Similarly, MK801 (0.5 and 1. μg/mouse) decreased memory consolidation, but had no effect on head-dip counts and head-dip latency. Interestingly, it increased locomotor activity. The results also showed that post-training intra-CA1 injection of a sub-threshold dose of RS67333 (6.25. ng/mouse) or RS23597 (0.1. ng/mouse) could heighten MK801 induced amnesia and decrease locomotor activity, but it did not alter head-dip counts and head-dip latency. In conclusion, our findings suggest that the CA1 5-HT4 receptors are involved in MK801-induced amnesia and hyperlocomotion. © 2014.
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