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Smart Mesoporous Silica Nanoparticles in Cancer: Diagnosis, Treatment, Immunogenicity, and Clinical Translation Publisher Pubmed



Yousefiasl S1 ; Ghovvati M2 ; Alibakhshi A3 ; Azizi M3, 4 ; Samadi P5 ; Kumar A6 ; Shojaeian A7 ; Sharifi E3, 4 ; Zare EN8 ; Dey AD9 ; Chehelgerdi M10 ; Makvandi P11, 12, 13
Authors
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Authors Affiliations
  1. 1. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  2. 2. Department of Radiological Sciences, David Geffen School of Medicine, University of California – Los Angeles, Los Angeles, 90095, CA, United States
  3. 3. Cancer Research Center, Institute of Cancer, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, 6517838636, Iran
  4. 4. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, 6517838736, Iran
  5. 5. Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, 8198314271, Iran
  6. 6. Department of Pharmacy, School of Health Sciences, Central University of South Bihar, Gaya, 824209, India
  7. 7. Research Center for Molecular Medicine, Institute of Cancer, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, 6517838636, Iran
  8. 8. School of Chemistry, Damghan University, Damghan, 36716-45667, Iran
  9. 9. Chitkara College of Pharmacy, Chitkara University, Punjab, India
  10. 10. Novin Genome (NG) Lab, Research and Development Center for Biotechnology, Shahrekord, Iran
  11. 11. The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China
  12. 12. University Centre for Research & Development, Chandigarh University, Punjab, Mohali, 140413, India
  13. 13. Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, 174103, India

Source: Small Published:2025


Abstract

In cancer research and personalized medicine, mesoporous silica nanoparticles (MSNs) have emerged as a significant breakthrough in both cancer treatment and diagnosis. MSNs offer targeted drug delivery, enhancing therapeutic effectiveness while minimizing adverse effects on healthy cells. Due to their unique characteristics, MSNs provide targeted drug delivery, maximizing therapeutic effectiveness with minimal adverse effects on healthy cells. The review thoroughly investigates the role of MSNs as potent drug carriers, noted for their high drug-loading capacity and controlled release, which significantly improves drug permeability and retention. Additionally, it discusses surface modification techniques that enable MSNs to target cancer cells precisely. The manuscript provides comprehensive insights into various MSN applications, including their role in cancer diagnosis, the design of advanced biosensors, and the development of both conventional and stimuli-responsive drug delivery platforms. Special focus is given to stimuli-triggered MSN systems, responsive to internal stimuli (e.g., pH, redox, enzyme) and external stimuli (e.g., temperature, magnetic field, light, ultrasound), highlighting the cutting-edge progress in MSN technology. Additionally, the review delves into the immunogenicity and biosafety aspects of MSNs, underscoring their potential for clinical translation. Besides summarizing the current state of MSN research in oncology, this review also illuminates the path for future advancements and clinical applications. © 2025 Wiley-VCH GmbH.
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