An Exon Variant in Insulin Receptor Gene Is Associated With Susceptibility to Colorectal Cancer in Women

An Exon Variant in Insulin Receptor Gene Is Associated With Susceptibility to Colorectal Cancer in Women Publisher Pubmed

Mahmoudi T¹ ; Majidzadeha K² ; Karimi K¹ ; Karimi N¹ ; Farahani H³ ; Dabiri R⁴ ; Nobakht H⁴ ; Dolatmoradi H¹ ; Arkani M¹ ; Zali MR¹

Show Affiliations

1. Department of Cancer, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Velenjak, Shahid Chamran Highway, Tehran, 1985711151, Iran
2. Cancer Genetics Department, Breast Cancer Research Center (BCRC), ACECR, Tehran, Iran
3. Department of Physiology, School of Medicine, Qom University of Medical Sciences, Qom, Iran
4. Internal Medicine Department, Semnan University of Medical Sciences, Semnan, Iran

Source: Tumor Biology Published:2015

Abstract

Given the role of insulin resistance in colorectal cancer (CRC), we explored whether genetic variants in insulin (INS), insulin receptor (INSR), insulin receptor substrate 1 (IRS1), insulin receptor substrate 2 (IRS2), insulin-like growth factor 1 (IGF1), and insulin-like growth factor binding protein 3 (IGFBP3) genes were associated with CRC risk. A total of 600 subjects, including 261 cases with CRC and 339 controls, were enrolled in this case-control study. Six polymorphisms in INS (rs689), INSR (rs1799817), IRS1 (rs1801278), IRS2 (rs1805097), IGF1 (rs5742612), and IGFBP3 (rs2854744) genes were genotyped using PCR-RFLP method. No significant difference was observed for INS, INSR, IRS1, IRS2, IGF1, and IGFBP3 genes between the cases and controls. However, the INSR rs1799817 “TT + CT” genotype and “CT” genotype compared with “CC” genotype occurred more frequently in the women with CRC than women controls (P = 0.007; OR = 1.93, 95 %CI = 1.20–3.11 and P = 0.002, OR = 2.15, 95 %CI = 1.31–3.53, respectively), and the difference remained significant after adjustment for confounding factors including age, BMI, smoking status, NSAID use, and family history of CRC (P = 0.018; OR = 1.86, 95 %CI = 1.11-3.10 and P = 0.004, OR = 2.18, 95 %CI = 1.28–3.71, respectively). In conclusion, to our knowledge, this study indicated for the first time that the INSR rs1799817 TT + CT genotype and CT genotype compared with the CC genotype had 1.86-fold and 2.18-fold increased risks for CRC among women, respectively. Furthermore, this finding is in line with previous studies which found significant associations between other variants of the INSR gene and CRC risk. Nevertheless, further studies are required to confirm our findings. © 2015, International Society of Oncology and BioMarkers (ISOBM).

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Style	Citing Format
MLA	Mahmoudi T, et al.. "An Exon Variant in Insulin Receptor Gene Is Associated With Susceptibility to Colorectal Cancer in Women." Tumor Biology, vol. 36, no. 5, 2015, pp. 3709-3715.
APA	Mahmoudi T, Majidzadeha K, Karimi K, Karimi N, Farahani H, Dabiri R, Nobakht H, Dolatmoradi H, Arkani M, Zali MR (2015). An Exon Variant in Insulin Receptor Gene Is Associated With Susceptibility to Colorectal Cancer in Women. Tumor Biology, 36(5), 3709-3715.
Chicago	Mahmoudi T, Majidzadeha K, Karimi K, Karimi N, Farahani H, Dabiri R, Nobakht H, Dolatmoradi H, Arkani M, Zali MR. "An Exon Variant in Insulin Receptor Gene Is Associated With Susceptibility to Colorectal Cancer in Women." Tumor Biology 36, no. 5 (2015): 3709-3715.
Harvard	Mahmoudi T et al. (2015) 'An Exon Variant in Insulin Receptor Gene Is Associated With Susceptibility to Colorectal Cancer in Women', Tumor Biology, 36(5), pp. 3709-3715.
Vancouver	Mahmoudi T, Majidzadeha K, Karimi K, Karimi N, Farahani H, Dabiri R, et al.. An Exon Variant in Insulin Receptor Gene Is Associated With Susceptibility to Colorectal Cancer in Women. Tumor Biology. 2015;36(5):3709-3715.
BibTex	@article{ author = {Mahmoudi T and Majidzadeha K and Karimi K and Karimi N and Farahani H and Dabiri R and Nobakht H and Dolatmoradi H and Arkani M and Zali MR}, title = {An Exon Variant in Insulin Receptor Gene Is Associated With Susceptibility to Colorectal Cancer in Women}, journal = {Tumor Biology}, volume = {36}, number = {5}, pages = {3709-3715}, year = {2015} }
RIS	TY - JOUR AU - Mahmoudi T AU - Majidzadeha K AU - Karimi K AU - Karimi N AU - Farahani H AU - Dabiri R AU - Nobakht H AU - Dolatmoradi H AU - Arkani M AU - Zali MR TI - An Exon Variant in Insulin Receptor Gene Is Associated With Susceptibility to Colorectal Cancer in Women JO - Tumor Biology VL - 36 IS - 5 SP - 3709 EP - 3715 PY - 2015 ER -

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