Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Injectable Cell-Laden Hydrogels for Tissue Engineering: Recent Advances and Future Opportunities Publisher Pubmed



Zarrintaj P1 ; Khodadadi Yazdi M2 ; Youssefi Azarfam M3 ; Zare M4 ; Ramsey JD1 ; Seidi F5 ; Reza Saeb M2 ; Ramakrishna S6, 7 ; Mozafari M8
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Chemical Engineering, Oklahoma State University, Stillwater, OK, United States
  2. 2. Center of Excellence in Electrochemistry, University of Tehran, Tehran, Iran
  3. 3. Department of Chemistry, Oklahoma State University, Stillwater, OK, United States
  4. 4. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Provincial Key Lab of Pulp and Paper Science and Technology, Joint International Research Lab of Lignocellulosic Functional Materials, Nanjing Forestry University, Nanjing, China
  6. 6. Center for Nanofibers and Nanotechnology, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Singapore, Singapore
  7. 7. Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore, 117581, Singapore
  8. 8. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Tissue Engineering - Part A Published:2021


Abstract

Tissue engineering intends to create functionalized tissues/organs for regenerating the injured parts of the body using cells and scaffolds. A scaffold as a supporting substrate affects the cells' fate and behavior, including growth, proliferation, migration, and differentiation. Hydrogel as a biomimetic scaffold plays an important role in cellular behaviors and tissue repair, providing a microenvironment close to the extracellular matrix with adjustable mechanical and chemical features that can provide sufficient nutrients and oxygen. To enhance the hydrogel performance and compatibility with native niche, the cell-laden hydrogel is an attractive choice to mimic the function of the targeted tissue. Injectable hydrogels, due to the injectability, are ideal options for in vivo minimally invasive treatment. Cell-laden injectable hydrogels can be utilized for tissue regeneration in a noninvasive way. This article reviews the recent advances and future opportunities of cell-laden injectable hydrogels and their functions in tissue engineering. It is expected that this strategy allows medical scientists to develop a minimally invasive method for tissue regeneration in clinical settings. Cell-laden hydrogels have been vastly utilized in biomedical application, especially tissue engineering. It is expected that this upcoming review article will be a motivation for the community. Although this strategy is still in its early stages, this concept is so alluring that it has attracted all scientists in the community and specialists at academic health centers. Certainly, this approach requires more development, and a bunch of crucial challenges have yet to be solved. In this review, we discuss this various aspects of this approach, the questions that must be answered, the expectations associated with it, and rational restrictions to develop injectable cell-laden hydrogels. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021.
Related Docs
View other Related Docs
1. Poloxamer: A Versatile Tri-Block Copolymer for Biomedical Applications, Acta Biomaterialia (2020)
2. Grafted Polysaccharides in Drug Delivery, Tailor-Made Polysaccharides in Drug Delivery (2022)
3. Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering, Polymers (2020)
4. Zeolite in Tissue Engineering: Opportunities and Challenges, MedComm (2020)
5. Cross-Linked Polysaccharides in Drug Delivery, Tailor-Made Polysaccharides in Drug Delivery (2022)
6. Copper-Enriched Diamond-Like Carbon Coatings Promote Regeneration at the Bone–Implant Interface, Heliyon (2020)
7. Thermo-Sensitive Polymers in Medicine: A Review, European Polymer Journal (2019)
8. Electrically Conductive Materials: Opportunities and Challenges in Tissue Engineering, Biomolecules (2019)
Experts (# of related papers)
View all Related Experts
Fatameh Mottaghitalab (5)
Rassoul Dinarvand (3)
Other Related Docs
9. Sustained Delivery of Olanzapine From Sunflower Oil-Based Polyol-Urethane Nanoparticles Synthesised Through a Cyclic Carbonate Ring-Opening Reaction, IET Nanobiotechnology (2019)
10. Conductive Biomaterials As Nerve Conduits: Recent Advances and Future Challenges, Applied Materials Today (2020)
11. From Microporous to Mesoporous Mineral Frameworks: An Alliance Between Zeolite and Chitosan, Carbohydrate Research (2020)
12. Zeolites in Drug Delivery: Progress, Challenges and Opportunities, Drug Discovery Today (2020)
13. Agarose-Based Biomaterials for Advanced Drug Delivery, Journal of Controlled Release (2020)
14. Turning Toxic Nanomaterials Into a Safe and Bioactive Nanocarrier for Co-Delivery of Dox/Pcrispr, ACS Applied Bio Materials (2021)
15. Chitosan/Polyvinyl Alcohol Nanofibrous Membranes: Towards Green Super-Adsorbents for Toxic Gases, Heliyon (2019)
16. Electroactive Bio-Epoxy Incorporated Chitosan-Oligoaniline As an Advanced Hydrogel Coating for Neural Interfaces, Progress in Organic Coatings (2019)
17. Injectable Hydrogels in Central Nervous System: Unique and Novel Platforms for Promoting Extracellular Matrix Remodeling and Tissue Engineering, Materials Today Bio (2023)
18. Mesenchymal Stem Cell Spheroids Embedded in an Injectable Thermosensitive Hydrogel: An in Situ Drug Formation Platform for Accelerated Wound Healing, ACS Biomaterials Science and Engineering (2020)
19. Highly Curable Self-Healing Vitrimer-Like Cellulose-Modified Halloysite Nanotube/Epoxy Nanocomposite Coatings, Chemical Engineering Journal (2020)
20. Carboxymethylated Polysaccharides in Drug Delivery, Tailor-Made Polysaccharides in Drug Delivery (2022)
21. Soft and Hard Sections From Cellulose-Reinforced Poly(Lactic Acid)-Based Food Packaging Films: A Critical Review, Food Packaging and Shelf Life (2020)
22. Thermosensitive Chitosan/Poly(N-Isopropyl Acrylamide) Nanoparticles Embedded in Aniline Pentamer/Silk Fibroin/Polyacrylamide As an Electroactive Injectable Hydrogel for Healing Critical-Sized Calvarial Bone Defect in Aging Rat Model, International Journal of Biological Macromolecules (2022)
23. Green and Sustainable Hydrogels Based on Quaternized Chitosan to Enhance Wound Healing, Chemical Engineering Journal (2024)
24. The Recent Advancement in the Chitosan-Based Thermosensitive Hydrogel for Tissue Regeneration, Journal of Drug Delivery Science and Technology (2023)
25. Nanocomposite Biomaterials Made by 3D Printing: Achievements and Challenges, Handbook of Polymer Nanocomposites for Industrial Applications (2020)
26. Engineering the Niche for Hair Regeneration — a Critical Review, Nanomedicine: Nanotechnology# Biology# and Medicine (2019)
27. Polydopamine Biomaterials for Skin Regeneration, ACS Biomaterials Science and Engineering (2022)
28. Biomaterials Selection for Neuroprosthetics, Current Opinion in Biomedical Engineering (2018)
29. Conductive Hydrogels Based on Tragacanth and Silk Fibroin Containing Dopamine Functionalized Carboxyl-Capped Aniline Pentamer: Merging Hemostasis, Antibacterial, and Anti-Oxidant Properties Into a Multifunctional Hydrogel for Burn Wound Healing, International Journal of Biological Macromolecules (2024)
30. Corneal Repair and Regeneration: Current Concepts and Future Directions, Frontiers in Bioengineering and Biotechnology (2019)
31. Clickable Polysaccharides for Biomedical Applications: A Comprehensive Review, Progress in Polymer Science (2022)
32. Self-Healable Conductive Polyurethane With the Body Temperature‐Responsive Shape Memory for Bone Tissue Engineering, Chemical Engineering Journal (2021)
33. Magnetic Nanoparticles in Cancer Therapy, Magnetic Nanoparticle-Based Hybrid Materials: Fundamentals and Applications (2021)
34. Niobium-Treated Titanium Implants With Improved Cellular and Molecular Activities at the Tissue-Implant Interface, Materials (2019)
35. Encapsulation of Cartilage Cells, Principles of Biomaterials Encapsulation: Volume 2 (2023)
36. Chitosan in Biomedical Engineering: A Critical Review, Current Stem Cell Research and Therapy (2019)
37. Encapsulation of Stem Cells, Principles of Biomaterials Encapsulation: Volume 2 (2023)
38. Synthesis, Characterization and Performance Enhancement of Dry Polyaniline-Coated Neuroelectrodes for Electroencephalography Measurement, Current Applied Physics (2021)
39. Agarose-Based Biomaterials for Tissue Engineering, Carbohydrate Polymers (2018)
40. Synthesis of Cost-Effective Hierarchical Mfi-Type Mesoporous Zeolite: Introducing Diatomite As Silica Source, Silicon (2021)
41. Regenerative Strategies for the Consequences of Myocardial Infarction: Chronological Indication and Upcoming Visions, Biomedicine and Pharmacotherapy (2022)
42. Clinical Challenges in Bone Tissue Engineering - a Narrative Review, Bone (2025)
43. Microfluidic-Based Droplets for Advanced Regenerative Medicine: Current Challenges and Future Trends, Biosensors (2022)
44. Inhibition of Hypertrophy and Improving Chondrocyte Differentiation by Mmp-13 Inhibitor Small Molecule Encapsulated in Alginate-Chondroitin Sulfate-Platelet Lysate Hydrogel, Stem Cell Research and Therapy (2020)
45. Sol-Gel Synthesis, Physico-Chemical and Biological Characterization of Cerium Oxide/Polyallylamine Nanoparticles, Polymers (2020)
46. Exploring the Potential of Polysaccharides-Based Injectable Self-Healing Hydrogels for Wound Healing Applications: A Review, International Journal of Biological Macromolecules (2024)
47. Human Umbilical Cord–Derived Mesenchymal Stem Cells Into Oligodendrocyte-Like Cells Using Triiodothyronine As an Inducer: A Rapid and Efficient Protocol, Regenerative Engineering and Translational Medicine (2023)
48. Synthesis of Thermogel Modified With Biomaterials As Carrier for Husscs Differentiation Into Cardiac Cells: Physicomechanical and Biological Assessment, Materials Science and Engineering C (2021)
49. Synthesis of Green Benzamide-Decorated Uio-66-Nh2 for Biomedical Applications, Chemosphere (2022)
50. Reduced Graphene Oxide–Reinforced Gellan Gum Thermoresponsive Hydrogels As a Myocardial Tissue Engineering Scaffold, Journal of Bioactive and Compatible Polymers (2019)