Therapeutic Approaches of Cell Therapy Based on Stem Cells and Terminally Differentiated Cells: Potential and Effectiveness Publisher Pubmed



Pirsadeghi A^{1, 2} ; Namakkoobi N^{3, 4} ; Behzadi MS³ ; Pourzinolabedin H³ ; Askari F^{1, 5} ; Shahabinejad E^{4, 5} ; Ghorbani S³ ; Asadi F^{6, 7} ; Hosseinichegeni A^{7, 8} ; Yousefiahmadipour A^{1, 3, 4, 6, 7} ; Kamrani MH¹ Show Affiliations
Source: Cells and Development Published:2024

Abstract

Cell-based therapy, as a promising regenerative medicine approach, has been a promising and effective strategy to treat or even cure various kinds of diseases and conditions. Generally, two types of cells are used in cell therapy, the first is the stem cell, and the other is a fully differentiated cell. Initially, all cells in the body are derived from stem cells. Based on the capacity, potency and differentiation potential of stem cells, there are four types: totipotent (produces all somatic cells plus perinatal tissues), pluripotent (produces all somatic cells), multipotent (produces many types of cells), and unipotent (produces a particular type of cells). All non-totipotent stem cells can be used for cell therapy, depending on their potency and/or disease state/conditions. Adult fully differentiated cell is another cell type for cell therapy that is isolated from adult tissues or obtained following the differentiation of stem cells. The cells can then be transplanted back into the patient to replace damaged or malfunctioning cells, promote tissue repair, or enhance the targeted organ's overall function. With increasing science and knowledge in biology and medicine, different types of techniques have been developed to obtain efficient cells to use for therapeutic approaches. In this study, the potential and opportunity of use of all cell types, both stem cells and fully differentiated cells, are reviewed. © 2024