Electrospun Biocompatible Poly (Ε-Caprolactonediol)-Based Polyurethane Core/Shell Nanofibrous Scaffold for Controlled Release of Temozolomide

Electrospun Biocompatible Poly (Ε-Caprolactonediol)-Based Polyurethane Core/Shell Nanofibrous Scaffold for Controlled Release of Temozolomide Publisher

Irani M¹ ; Mir Mohamad Sadeghi G² ; Haririan I³

Show Affiliations

1. Department of Chemical Engineering, Amirkabir University of Technology, Tehran, Iran
2. Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran
3. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2018

Abstract

The electrospun biocompatible poly (ε-caprolactonediol)-based polyurethane (PCL-Diol-b-PU) core/shell nanofibrous scaffolds were prepared via the coaxial electrospinning process. Temozolomide (TMZ) as an anticancer drug was loaded into the core of fibers to control the release of TMZ for the treatment of glioblastoma. The properties of nanofibers were characterized using XRD, FTIR, SEM, and TEM analysis. The sustained delivery of TMZ without initial burst release was achieved from all prepared core–shell nanofibrous samples over 30 days. The cytotoxicity results revealed that the TMZ-loaded PCL-Diol-b-PU core–shell nanofibers could be used as a drug delivery implant to deliver TMZ against glioblastoma tumors. © 2017 Taylor & Francis.

Style	Citing Format
MLA	Irani M, Mir Mohamad Sadeghi G, Haririan I. "Electrospun Biocompatible Poly (Ε-Caprolactonediol)-Based Polyurethane Core/Shell Nanofibrous Scaffold for Controlled Release of Temozolomide." International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 67, no. 6, 2018, pp. 361-366.
APA	Irani M, Mir Mohamad Sadeghi G, Haririan I (2018). Electrospun Biocompatible Poly (Ε-Caprolactonediol)-Based Polyurethane Core/Shell Nanofibrous Scaffold for Controlled Release of Temozolomide. International Journal of Polymeric Materials and Polymeric Biomaterials, 67(6), 361-366.
Chicago	Irani M, Mir Mohamad Sadeghi G, Haririan I. "Electrospun Biocompatible Poly (Ε-Caprolactonediol)-Based Polyurethane Core/Shell Nanofibrous Scaffold for Controlled Release of Temozolomide." International Journal of Polymeric Materials and Polymeric Biomaterials 67, no. 6 (2018): 361-366.
Harvard	Irani M, Mir Mohamad Sadeghi G, Haririan I (2018) 'Electrospun Biocompatible Poly (Ε-Caprolactonediol)-Based Polyurethane Core/Shell Nanofibrous Scaffold for Controlled Release of Temozolomide', International Journal of Polymeric Materials and Polymeric Biomaterials, 67(6), pp. 361-366.
Vancouver	Irani M, Mir Mohamad Sadeghi G, Haririan I. Electrospun Biocompatible Poly (Ε-Caprolactonediol)-Based Polyurethane Core/Shell Nanofibrous Scaffold for Controlled Release of Temozolomide. International Journal of Polymeric Materials and Polymeric Biomaterials. 2018;67(6):361-366.
BibTex	@article{ author = {Irani M and Mir Mohamad Sadeghi G and Haririan I}, title = {Electrospun Biocompatible Poly (Ε-Caprolactonediol)-Based Polyurethane Core/Shell Nanofibrous Scaffold for Controlled Release of Temozolomide}, journal = {International Journal of Polymeric Materials and Polymeric Biomaterials}, volume = {67}, number = {6}, pages = {361-366}, year = {2018} }
RIS	TY - JOUR AU - Irani M AU - Mir Mohamad Sadeghi G AU - Haririan I TI - Electrospun Biocompatible Poly (Ε-Caprolactonediol)-Based Polyurethane Core/Shell Nanofibrous Scaffold for Controlled Release of Temozolomide JO - International Journal of Polymeric Materials and Polymeric Biomaterials VL - 67 IS - 6 SP - 361 EP - 366 PY - 2018 ER -

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